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Therefore, we evaluated the efficacy of non\u2010real\u2010time image\u2010guided transnasal endoscopic fine\u2010needle aspiration biopsy (FNAB) in diagnosing nasopharyngeal carcinoma (NPC) with submucosal lesions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>The effectiveness evaluation of diagnostic methods.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Fifty suspected NPC patients who failed in conventional biopsies were enrolled in this study. The efficacy, maneuverability, and safety of FNAB in diagnosing these intractable cases were evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The definitive diagnostic results of these 50 patients were NPC (34\/50, 68.0%), nasopharyngeal necrosis (1\/50, 2.0%), nasopharyngeal mucositis (12\/50, 24.0%), and other cancers (3\/50, 6.0%), respectively. The results of the diagnostic efficacy of FNAB were sensitivity, 89.2%; specificity, 100.0%; positive predictive value, 100.0%; negative predictive value, 76.5%; and accuracy, 92.0%, respectively. The area under the receiver operating characteristic curves was 0.946 (95% confidence interval\u00a0=\u00a00.884\u20131.00, <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001). No severe complications occurred after FNAB.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>FNAB can improve the diagnostic efficiency of NPC occurring in the submucosal space. It can be an additional option for routine nasopharyngeal biopsy and is worthy of clinical application.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>4 <jats:italic>Laryngoscope<\/jats:italic>, 131:1798\u20131804, 2021<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.29433","type":"journal-article","created":{"date-parts":[[2021,2,22]],"date-time":"2021-02-22T11:17:22Z","timestamp":1613992642000},"page":"1798-1804","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Efficacy of Transnasal Endoscopic Fine\u2010Needle Aspiration Biopsy in Diagnosing Submucosal Nasopharyngeal Carcinoma"],"prefix":"10.1002","volume":"131","author":[{"given":"Qing\u2010Nan","family":"Tang","sequence":"first","affiliation":[{"name":"Sun Yat\u2010sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of 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