{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T23:35:49Z","timestamp":1791416149133,"version":"4.3.3"},"reference-count":14,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2021,2,22]],"date-time":"2021-02-22T00:00:00Z","timestamp":1613952000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2021,9]]},"abstract":"\n Objectives\/Hypothesis<\/jats:title>\n To assess the long\u2010term (12\u201324\u2009months) safety and effectiveness of cryoablation of the posterior nasal nerve as treatment for chronic rhinitis.<\/jats:p>\n <\/jats:sec>\n \n Study Design<\/jats:title>\n A multicenter, prospective, single\u2010arm clinical study.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n The study was conducted from February 2017 to April 2020. Study endpoints included change from baseline in the reflective Total Nasal Symptom Score (rTNSS), Rhinoconjunctivitis Quality of Life Questionnaire (RQLQ), physician assessment of improvement using the Clinical Global Impression\u2013Improvement (CGI\u2013I), and the incidence of treatment\u2010related adverse events.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Ninety\u2010one participants completed the study through the initial 12\u2010month study period. Sixty\u2010two participants consented to the long\u2010term follow\u2010up with 57 completing the 24\u2010month follow\u2010up. Significant improvements in the total rTNSS were reflected in a median change from baseline of \u22123.0 or \u22124.0 at all timepoints (\n P<\/jats:italic>\n \u2009<\u2009.001). Greater than 80.0% of participants achieved the minimum clinically important difference (MCID) of improvement by \u22651 point on the rTNSS at all follow\u2010ups. Total RQLQ scores indicated significant improvement (\n P<\/jats:italic>\n \u2009<\u2009.0001) in quality of life. Over 77% of participants achieved the MCID (\u22650.5 points) for the total RQLQ score. According to the CGI\u2013I, \u226583.0% experienced improvement at all but the 12\u2010month visit (61.9%). One participant experienced two treatment\u2010related serious adverse events (epistaxis and retained pledget). A total of 29 nonserious treatment\u2010related AEs were reported in 23 participants; most events were transient and resolved with little to no intervention.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n Cryotherapy significantly and clinically improves rhinitis symptoms and quality of life with outcomes that are durable through 24\u2009months after treatment.<\/jats:p>\n <\/jats:sec>\n \n Level of Evidence<\/jats:title>\n \n 4\n Laryngoscope<\/jats:italic>\n , 131:1952\u20131957, 2021\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/lary.29453","type":"journal-article","created":{"date-parts":[[2021,2,22]],"date-time":"2021-02-22T06:19:22Z","timestamp":1613974762000},"page":"1952-1957","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["Cryosurgical Ablation for Treatment of Rhinitis:\n Two\u2010Year<\/scp>\n Results of a Prospective Multicenter Study"],"prefix":"10.1002","volume":"131","author":[{"given":"Randall A.","family":"Ow","sequence":"first","affiliation":[{"name":"Sacramento Ear, Nose, and Throat Roseville CA U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3751-764X","authenticated-orcid":false,"given":"Ellen M.","family":"O'Malley","sequence":"additional","affiliation":[{"name":"Clinical Affairs, Stryker ENT Plymouth MN U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph K.","family":"Han","sequence":"additional","affiliation":[{"name":"Otolaryngology Eastern Virginia Medical School Norfolk VA U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kent K.","family":"Lam","sequence":"additional","affiliation":[{"name":"Otolaryngology Eastern Virginia Medical School Norfolk VA U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David M.","family":"Yen","sequence":"additional","affiliation":[{"name":"Specialty Physician Associates Bethlehem PA 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Laryngoscope"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lary.29453","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/lary.29453","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lary.29453","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T23:25:10Z","timestamp":1693265110000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/lary.29453"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2,22]]},"references-count":14,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2021,9]]}},"alternative-id":["10.1002\/lary.29453"],"URL":"https:\/\/doi.org\/10.1002\/lary.29453","archive":["Portico"],"relation":{},"ISSN":["0023-852X","1531-4995"],"issn-type":[{"value":"0023-852X","type":"print"},{"value":"1531-4995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,2,22]]},"assertion":[{"value":"2020-11-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication 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