{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T23:35:54Z","timestamp":1783121754015,"version":"3.54.6"},"reference-count":69,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2021,2,18]],"date-time":"2021-02-18T00:00:00Z","timestamp":1613606400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate blood pressure (BP) variability in 24\u2010hour ambulatory BP monitoring in children with obstructive sleep apnea (OSA).<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Case series study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Children aged 4 to 16\u2009years with clinical symptoms were recruited in a tertiary medical center. Overnight polysomnography and 24\u2010hour recordings of ambulatory BP were performed for each child. The severity of OSA was classified as primary snoring (apnea\u2010hypopnea index [AHI]\u2009&lt;\u20091), mild OSA (1\u2009\u2264\u2009AHI\u2009&lt;\u20095), moderate OSA (10\u2009&gt;\u2009AHI\u2009\u2265\u20095), and severe OSA (AHI\u2009\u2265\u200910). The standard deviation of mean BP was used as an indicator of BP variability.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 550 children were included (mean age: 7.6\u2009years; 70% were boys; 20% were obese). Compared with the children with primary snoring, children with severe OSA exhibited significantly higher nighttime systolic BP (108.0 vs. 100.5\u2009mmHg, <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001), nighttime diastolic BP (58.9 vs 55.6\u2009mmHg, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.002), nighttime mean arterial pressure (75.3 vs. 70.5\u2009mmHg, <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001), nighttime systolic BP load (40.5% vs. 25.0%, <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001), nighttime diastolic BP load (25.3% vs. 12.9%, <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001), and nighttime systolic BP variability (11.4 vs. 9.6, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.001). Multiple linear regression analyses revealed an independent association between AHI and nighttime systolic BP variability (regression coefficient\u00a0=\u00a00.31, 95% CI\u00a0=\u00a00.06\u20130.56, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.015) after adjustment for age, gender, adiposity, and hypertensive status.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>OSA in children is associated with increased BP and BP variability.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>4 <jats:italic>Laryngoscope<\/jats:italic>, 131:2126\u20132132, 2021<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.29455","type":"journal-article","created":{"date-parts":[[2021,2,20]],"date-time":"2021-02-20T18:47:46Z","timestamp":1613846866000},"page":"2126-2132","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["24\u2010Hour Ambulatory Blood Pressure Variability in Children with Obstructive Sleep Apnea"],"prefix":"10.1002","volume":"131","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4421-9261","authenticated-orcid":false,"given":"Kun\u2010Tai","family":"Kang","sequence":"first","affiliation":[{"name":"Department of Otolaryngology National Taiwan University Hospital  Taipei Taiwan"},{"name":"Department of Otolaryngology, Taipei Hospital Ministry of Health and Welfare  New Taipei City Taiwan"},{"name":"Institute of Health Policy and Management National Taiwan University  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuenn\u2010Nan","family":"Chiu","sequence":"additional","affiliation":[{"name":"Department of Pediatrics National Taiwan University Hospital  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen\u2010Chin","family":"Weng","sequence":"additional","affiliation":[{"name":"Department of Pediatrics National Taiwan University Hospital  Taipei Taiwan"},{"name":"Sleep Center National Taiwan University Hospital  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pei\u2010Lin","family":"Lee","sequence":"additional","affiliation":[{"name":"Sleep Center National Taiwan University Hospital  Taipei Taiwan"},{"name":"Department of Internal Medicine National Taiwan University Hospital  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8583-8459","authenticated-orcid":false,"given":"Wei\u2010Chung","family":"Hsu","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology National Taiwan University Hospital  Taipei Taiwan"},{"name":"Sleep Center National Taiwan University Hospital  Taipei Taiwan"},{"name":"Department of Otolaryngology, College of Medicine National Taiwan University  Taipei 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