{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T17:07:50Z","timestamp":1783444070356,"version":"3.54.6"},"reference-count":29,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2021,3,4]],"date-time":"2021-03-04T00:00:00Z","timestamp":1614816000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:sec><jats:title>Objectives\/Hypothesis<\/jats:title><jats:p>The efficacy of short\u2010term oral corticosteroids in chronic rhinosinusitis without nasal polyps (CRSsNP) is unknown. The aim of this controlled study was to assess the immediate and long\u2010term outcomes from a short course of a commonly used oral corticosteroid, prednisolone, in well\u2010defined CRSsNP patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Prospective, observational controlled study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A prospective\u2010controlled study of CRSsNP patients treated with prednisolone at 0.5\u2009mg\/kg tapered over 10\u2009days and non\u2010prednisolone treated CRSsNP patients (controls) and follow\u2010up at 2, 6, and 12\u2009months. Baseline and follow\u2010up SinoNasal Outcome Test (SNOT)\u201022, nasal endoscopy (Lund\u2010Kennedy), and sinus CT scan scores (Lund\u2010Mackay) were compared.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At 2\u2009months, there was a significant improvement in the SNOT\u201022, nasal endoscopy, and sinus CT scan scores in the prednisolone group (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.0001) compared with controls (p\u00a0=\u00a0ns, Mann\u2013Whitney <jats:italic>U<\/jats:italic> test). 52.5% of prednisolone\u2010treated CRSsNP patients had improved symptoms and did not require sinus surgery at 12\u2009months compared with 14.3% of controls (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001). Side\u2010effects were reported in 8.9% of prednisolone\u2010treated patients. Patients who benefited from prednisolone had a median symptom duration of 7.25 (99% confidence, upper limit of 11) months compared with 18\u2009months in those requiring surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Short\u2010term oral prednisolone significantly improved all three clinical measures of disease in CRSsNP patients and avoided surgical intervention in 52.5% patients in the first 12\u2009months. Patients with symptoms for less than 11\u2009months were most likely to benefit. The side\u2010effects of oral steroids require careful consideration and further studies are needed to ascertain appropriate dosage and treatment duration.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>3 <jats:italic>Laryngoscope<\/jats:italic>, 131:E2618\u2013E2626, 2021<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.29495","type":"journal-article","created":{"date-parts":[[2021,3,4]],"date-time":"2021-03-04T11:17:04Z","timestamp":1614856624000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Short\u2010term Oral Steroids Significantly Improves Chronic Rhinosinusitis Without Nasal Polyps"],"prefix":"10.1002","volume":"131","author":[{"given":"April P.","family":"De Silva","sequence":"first","affiliation":[{"name":"Adelaide School of Medicine The University of Adelaide  Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark A.","family":"Schembri","sequence":"additional","affiliation":[{"name":"Adelaide School of Medicine The University of Adelaide  Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angus H.","family":"Sarah","sequence":"additional","affiliation":[{"name":"Adelaide School of Medicine The University of Adelaide  Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Chao","sequence":"additional","affiliation":[{"name":"Centre for Cancer Biology University of South Australia and SA Pathology  Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kwok Ho","family":"Yip","sequence":"additional","affiliation":[{"name":"Centre for Cancer Biology University of South Australia and SA Pathology  Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00f6khan","family":"Cildir","sequence":"additional","affiliation":[{"name":"Centre for Cancer Biology University of South Australia and SA Pathology  Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angel","family":"Lopez","sequence":"additional","affiliation":[{"name":"Centre for Cancer Biology University of South Australia and SA Pathology  Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Damon J.","family":"Tumes","sequence":"additional","affiliation":[{"name":"Centre for Cancer Biology University of South Australia and SA Pathology  Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9388-193X","authenticated-orcid":false,"given":"Harshita","family":"Pant","sequence":"additional","affiliation":[{"name":"Adelaide School of 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