{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T17:49:24Z","timestamp":1790704164943,"version":"4.1.0"},"reference-count":29,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2021,3,12]],"date-time":"2021-03-12T00:00:00Z","timestamp":1615507200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:sec><jats:title>Objectives\/Hypothesis<\/jats:title><jats:p>To explore the clinically feasible diagnosis criteria and treatment outcomes of allergy\u2010related sialodochitis (ARS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Prospective Cohort Study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Ninety\u2010six consecutive patients were enrolled by the following criteria: 1) recurrent swelling of \u22652 large salivary glands that lasted for \u22653\u2009months; 2) with mucus plug exudations; 3) with atopic diseases; 4) ductal stenosis and\/or ectasia. Sixty\u2010four patients with elevation of peripheral blood eosinophil (PBE) and\/or serum IgE level comprised group A (highly\u2010suspected ARS group), while the remaining 32 comprised group B (patients without confirmed evidence of ARS). These patients were treated with interventional endoscopy. A chronic obstructive sialadenitis symptom (COSS) questionnaire was used to quantify the treatment outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In group A, Serum IgE was elevated in 84.4% of patients and PBE was elevated in 34.4% of patients. Percentage of submandibular gland involvement was higher in group A than group B (48.4% vs. 18.8%). On sialograms, the snowflake changes of branch ducts were seen in higher percentage of group A compared with group B (59% vs. 35% for parotid glands, 27% vs. 8% for submandibular glands, respectively). Mucus plug smears showed abundant eosinophils in 14 group A patients. Biopsy of five group A patients revealed significant eosinophil infiltration around the main and interlobular ducts. During follow\u2010up, the COSS scores were significantly decreased in both groups, and group B was improved better than group A.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>PBE and serum IgE are important diagnostic indexes of ARS. Mucus plug smear or histopathology verifies the diagnosis. Interventional endoscopy is helpful for ARS cases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>3 <jats:italic>Laryngoscope<\/jats:italic>, 131:2030\u20132035, 2021<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.29508","type":"journal-article","created":{"date-parts":[[2021,3,12]],"date-time":"2021-03-12T12:08:04Z","timestamp":1615550884000},"page":"2030-2035","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Allergy\u2010Related Sialodochitis: A Preliminary Cohort Study"],"prefix":"10.1002","volume":"131","author":[{"given":"Ya\u2010Ning","family":"Zhao","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial Radiology Peking University School and Hospital of Stomatology &amp; National Engineering Laboratory for Digital and Material Technology of Stomatology &amp; Beijing Key Laboratory of Digital Stomatology  Beijing People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li\u2010Qi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Radiology Peking University School and Hospital of Stomatology &amp; National Engineering Laboratory for Digital and Material Technology of Stomatology &amp; Beijing Key Laboratory of Digital Stomatology  Beijing People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya\u2010Qiong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Radiology Peking University School and Hospital of Stomatology &amp; National Engineering Laboratory for Digital and Material Technology of Stomatology &amp; Beijing Key Laboratory of Digital Stomatology  Beijing People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology Peking University School and Hospital of Stomatology &amp; National Engineering Laboratory for Digital and Material Technology of Stomatology &amp; Beijing Key Laboratory of Digital Stomatology  Beijing People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8917-0003","authenticated-orcid":false,"given":"Deng\u2010Gao","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Radiology Peking University School and Hospital of Stomatology &amp; National Engineering Laboratory for Digital and Material Technology of Stomatology &amp; Beijing Key Laboratory of Digital Stomatology  Beijing People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guang\u2010Yan","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery Peking University School and Hospital of Stomatology &amp; National 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