{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T17:07:33Z","timestamp":1780938453384,"version":"3.54.1"},"reference-count":21,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2021,3,15]],"date-time":"2021-03-15T00:00:00Z","timestamp":1615766400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:sec><jats:title>Objectives\/Hypothesis<\/jats:title><jats:p>To compare effect of 1 and 2\u2009mg\/kg of sugammadex on the incidence of intraoperative bucking and intraoperative neuromonitoring (IONM) quality in thyroid surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Randomized controlled trial.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients qualified for thyroid surgery with IONM were eligible for this double\u2010blind, randomized, controlled trial. After tracheal intubation with 0.6\u2009mg\/kg rocuronium, 1 or 2\u2009mg\/kg of sugammadex was administered to patients in group I or II, respectively. The quality of the IONM for the external branch of the superior laryngeal nerve (EBSLN) was evaluated (strong\/intermediate\/weak). The initial amplitude of electromyography for the vagus nerve (V1) and the recurrent laryngeal nerve (R1) were recorded. Intraoperative bucking movements was recorded.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 102 patients (51 in each group) completed the study. Time from sugammadex administration to initial checking for the EBSLN was not different between group I and II (25.0\u2009\u00b1\u20097.9 vs. 25.5\u2009\u00b1\u20099.0\u2009minutes, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.788). There was no difference in the neuromonitoring quality for the EBSLN between group I and II (strong\/intermediate\/weak: 46\/5\/0 vs. 50\/1\/0, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.205). The amplitudes of V1 (1,086.3\u2009\u00b1\u2009673.3\u2009\u03bcV vs. 1,161.8\u2009\u00b1\u2009727.5\u2009\u03bcV, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.588) and R1 (1,328.2\u2009\u00b1\u2009934.1\u2009\u03bcV vs. 1,410.5\u2009\u00b1\u2009919.6\u2009\u03bcV, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.655) were comparable between the groups. Patients who experienced bucking were significantly fewer in the group I than the group II (13.7% vs. 35.3%, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.020).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>A dose of 1\u2009mg\/kg sugammadex induced less bucking than 2\u2009m\/kg while providing comparable IONM quality during thyroid surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>2 <jats:italic>Laryngoscope<\/jats:italic>, 131:2154\u20132159, 2021<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.29515","type":"journal-article","created":{"date-parts":[[2021,3,15]],"date-time":"2021-03-15T10:39:24Z","timestamp":1615804764000},"page":"2154-2159","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Comparison of Sugammadex Dose for Intraoperative Neuromonitoring in Thyroid Surgery: A Randomized Controlled Trial"],"prefix":"10.1002","volume":"131","author":[{"given":"Young Jun","family":"Chai","sequence":"first","affiliation":[{"name":"Department of Surgery Seoul Metropolitan Government Seoul National University Boramae Medical Center, Seoul National University College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7115-2939","authenticated-orcid":false,"given":"Jung\u2010Man","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Pain Medicine Seoul Metropolitan Government Seoul National University Boramae Medical Center, Seoul National University College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongwook","family":"Won","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Pain Medicine Seoul Metropolitan Government Seoul National University Boramae Medical Center, Seoul National University College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiwon","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Pain Medicine Anesthesia and Pain Research Institute, Yonsei University College of Medicine, Gangnam Severance Hospital  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin\u2010Young","family":"Hwang","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Pain Medicine Seoul Metropolitan Government Seoul National University Boramae Medical Center, Seoul National University College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tae Kyong","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Pain Medicine Seoul Metropolitan Government Seoul National University Boramae Medical Center, Seoul National University College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jee\u2010Eun","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Pain Medicine Seoul Metropolitan Government Seoul National University Boramae Medical Center, Seoul National University College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyerim","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Pain Medicine Seoul Metropolitan Government Seoul National University Boramae Medical Center, Seoul National University College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyo Jun","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Pain Medicine Seoul National University Hospital  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seong\u2010Won","family":"Min","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Pain Medicine Seoul Metropolitan Government Seoul National University Boramae Medical Center, Seoul National University College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,3,15]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.26166"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.25577"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.4174\/astr.2019.97.6.282"},{"key":"e_1_2_6_5_1","first-page":"19","article-title":"Intraoperative rocuronium reversion by low doses of sugammadex, in thyroid surgery, with monitoring of the recurrent laryngeal nerves","volume":"1","author":"Margarita Kontoudi MG","year":"2016","journal-title":"ARC 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