{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T04:43:16Z","timestamp":1788410596677,"version":"build-2803163510"},"reference-count":35,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2021,3,26]],"date-time":"2021-03-26T00:00:00Z","timestamp":1616716800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100013699","name":"Ohio State University Comprehensive Cancer Center \u2013 Arthur G. James Cancer Hospital and Richard J. Solove Research Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100013699","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Chronic rhinosinusitis (CRS) is a heterogeneous group of inflammatory sinonasal disorders with key defining symptoms, but traditionally separated into phenotypes by clinical\/endoscopic findings. It is not known whether the two phenotypes have differing socioeconomic, comorbidity, and lifestyle differences. This analysis of the Chronic Rhinosinusitis Epidemiology Study (CRES) database sought to analyze any key differences in the socioeconomic variables between those with CRS with nasal polyps (CRSwNPs) and those without nasal polyps (CRSsNPs). We also sought to analyze differences in comorbidities, lifestyle, and quality of life.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with a confirmed diagnosis of CRS in secondary and tertiary care outpatient settings in the UK were invited to participate in a questionnaire\u2010based case\u2013control study. Variables included demographics, socioeconomic factors, comorbidities, lifestyle factors, and health\u2010related quality of life (HRQoL) (level 3 evidence).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 1204 patients' data were analyzed: 553 CRSsNP and 651 CRSwNP participants. The key socioeconomic variables did not demonstrate any notable differences, nor did lifestyle variables other than alcohol consumption being higher in those with CRSwNP (<jats:italic>P<\/jats:italic>\u00a0=\u2009.032), but the latter was not significant after adjusting for age and sex. Aside from confirmation of asthma being more common in CRSwNP, it was notable that this group complained less of upper respiratory tract infections (URTIs), and CRSsNP participants showed evidence of worse HRQoL scores in respect of body pain (<jats:italic>P<\/jats:italic>\u00a0=\u2009.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Patients with CRSwNP experience higher rates of asthma and lower rates of URTIs; patients with CRSsNP have worse body pain scores. Otherwise, there are no demonstrable significant socioeconomic, comorbidity, lifestyle, or quality of life differences between the two phenotypes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>3 <jats:italic>Laryngoscope<\/jats:italic>, 131:2179\u20132186, 2021<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.29527","type":"journal-article","created":{"date-parts":[[2021,3,26]],"date-time":"2021-03-26T11:10:19Z","timestamp":1616757019000},"page":"2179-2186","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Socioeconomic, comorbidity, lifestyle, and quality of life comparisons between chronic rhinosinusitis phenotypes"],"prefix":"10.1002","volume":"131","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1125-3236","authenticated-orcid":false,"given":"Carl","family":"Philpott","sequence":"first","affiliation":[{"name":"James Paget University Hospital NHS Foundation Trust  Gorleston UK"},{"name":"Norwich Medical School, University of East Anglia  Norfolk UK"},{"name":"Norfolk and Norwich University Hospital  Norwich UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8747-5329","authenticated-orcid":false,"given":"Ngan Hong","family":"Ta","sequence":"additional","affiliation":[{"name":"Norwich Medical School, University of East Anglia  Norfolk UK"},{"name":"Norfolk and Norwich University Hospital  Norwich UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire","family":"Hopkins","sequence":"additional","affiliation":[{"name":"Guys &amp; St Thomas' Hospital  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaydip","family":"Ray","sequence":"additional","affiliation":[{"name":"Sheffield Teaching Hospitals  UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shazhada","family":"Ahmed","sequence":"additional","affiliation":[{"name":"University Hospitals Birmingham  UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Almeyda","sequence":"additional","affiliation":[{"name":"Royal Berkshire NHS Foundation Trust  Reading UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naveed","family":"Kara","sequence":"additional","affiliation":[{"name":"Sunderland Royal Infirmary  UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sean","family":"Carrie","sequence":"additional","affiliation":[{"name":"Freeman Hospital  Newcastle UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sally E.","family":"Erskine","sequence":"additional","affiliation":[{"name":"Norwich Medical School, University of East Anglia  Norfolk UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Russell","family":"Cathcart","sequence":"additional","affiliation":[{"name":"Jersey General Hospital  British Isles Jersey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vishnu","family":"Sunkaraneni","sequence":"additional","affiliation":[{"name":"Royal Surrey County Hospital  Guildford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alasdair","family":"Robertson","sequence":"additional","affiliation":[{"name":"Southern General Hospital  Glasgow UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shahram","family":"Anari","sequence":"additional","affiliation":[{"name":"University Hospitals Birmingham  UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Balasubrahmanyam Nirmal","family":"Kumar","sequence":"additional","affiliation":[{"name":"Wrightington, Wigan &amp; Leigh NHS Foundation Trust  UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allan","family":"Clark","sequence":"additional","affiliation":[{"name":"Norwich Medical School, University of East Anglia  Norfolk UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"The CRES Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,3,26]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.4193\/Rhin20.401"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12931-018-0823-y"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2018-027528"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/crj.12780"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.4193\/Rhin15.272"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11882-018-0763-0"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoto.2020.4354"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoto.2015.3142"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599817745269"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/coa.12462"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.4193\/Rhin15.361"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/coa.12667"},{"key":"e_1_2_7_14_1","first-page":"1","article-title":"Managing chronic rhinosinusitis and respiratory disease: a qualitative study of triggers and interactions","volume":"24","author":"Erskine S","year":"2014","journal-title":"J Asthma"},{"key":"e_1_2_7_15_1","doi-asserted-by":"crossref","first-page":"e006680","DOI":"10.1136\/bmjopen-2014-006680","article-title":"The burden of revision sinonasal surgery in the UK\u2010data from the chronic rhinosinusitis epidemiology study (CRES): a cross\u2010sectional study","volume":"2015","author":"Philpott C","year":"2015","journal-title":"BMJ Open"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.4193\/Rhin16.111"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.4193\/Rhin17.165"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/coa.13012"},{"key":"e_1_2_7_19_1","first-page":"303","article-title":"Exploring the association between ingestion of foods with higher potential salicylate content and symptom exacerbation in chronic rhinosinusitis. Data from the National Chronic Rhinosinusitis Epidemiology Study","volume":"57","author":"Philpott CM","year":"2019","journal-title":"Rhinology"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-147-8-200710160-00010"},{"key":"e_1_2_7_21_1","first-page":"1","article-title":"European position paper on rhinosinusitis and nasal polyps 2012","volume":"23","author":"Fokkens WJ","year":"2012","journal-title":"Rhinol Suppl"},{"key":"e_1_2_7_22_1","unstructured":"Health Survey for England. Available at:https:\/\/digital.nhs.uk\/data-and-information\/publications\/statistical\/health-survey-for-england\/2018\/health-survey-for-england-2018-data-tables"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-4486.2006.01275.x"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2017.09.009"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599815580978"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.22256"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.4193\/Rhin19.424"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2019.00415"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2016.09.015"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.26901"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.26778"},{"key":"e_1_2_7_32_1","first-page":"420","article-title":"Antibiotic usage in chronic rhinosinusitis: analysis of national primary care electronic health records","volume":"57","author":"Hopkins C","year":"2019","journal-title":"Rhinology"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1177\/1945892420927244"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.121.6.1841"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.2105\/AJPH.2004.048967"},{"key":"e_1_2_7_36_1","first-page":"1072","article-title":"Factors associated with severe asthma","volume":"37","author":"Ratageri VH","year":"2000","journal-title":"Indian Pediatr"}],"container-title":["The Laryngoscope"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lary.29527","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/lary.29527","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lary.29527","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,25]],"date-time":"2023-08-25T08:03:14Z","timestamp":1692950594000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/lary.29527"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,26]]},"references-count":35,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2021,10]]}},"alternative-id":["10.1002\/lary.29527"],"URL":"https:\/\/doi.org\/10.1002\/lary.29527","archive":["Portico"],"relation":{},"ISSN":["0023-852X","1531-4995"],"issn-type":[{"value":"0023-852X","type":"print"},{"value":"1531-4995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,3,26]]},"assertion":[{"value":"2020-12-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-03-12","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-03-26","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}