{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T13:41:56Z","timestamp":1785418916026,"version":"3.56.0"},"reference-count":27,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2021,3,23]],"date-time":"2021-03-23T00:00:00Z","timestamp":1616457600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:sec><jats:title>Objectives\/Hypothesis<\/jats:title><jats:p>To assess the disease control, survival rates, and prognostic factors of exclusive surgical treatment for patients with pT3 N0 laryngeal squamous cell carcinoma (LSCC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Multicentric retrospective cohort study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Multicentric retrospective case series of previously untreated patients with pT3 R0N0 LSCC, who received exclusive surgery between 2011 and 2019. Tumor location; subsite involvement; grading; and lymphatic, vascular, and perineural invasion were reported. Overall survival (OS), disease\u2010specific survival (DSS), and disease\u2010free survival (DFS) were measured.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fifty\u2010four patients (mean age 67.1; male sex 83.3%; mean follow\u2010up period 37\u2009months) underwent total laryngectomy (48.1%) or partial laryngectomy (51.9%). Ipsilateral or bilateral neck dissection was performed in 46 (85.2%) cases. Perineural invasion was more frequent in case of supraglottic involvement than glottic involvement (85.7% vs. 14.3%, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.03). Five (9.3%) patients experienced recurrence (3 local recurrences, 1 nodal recurrence, 1 distant recurrence). Rate of recurrence differed between glottic (0%), supraglottic (80%), and transglottic (20%) tumors (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.01), with a lower risk yielded by glottic involvement (odds ratio [OR], 0.05, 95% confidence interval [95% CI], 0.01\u20130.56, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.01). A higher risk was recorded in case of perineural invasion (OR, 66.0, 95% CI, 1.41\u20133085.3, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.03). The OS, DSS, and DFS were 79.6%, 96.3%, and 90.7%, without differences regarding the type of surgery. The DFS was lower in case of supraglottic involvement when compared to purely glottic LSCC (83.9% vs. 100%, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.02).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Exclusive surgery is a safe option for patients with pT3 R0N0 LSCC. Adjuvant treatments or closer follow\u2010up monitoring might be considered in case of supraglottic involvement or perineural invasion.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>4 <jats:italic>Laryngoscope<\/jats:italic>, 131:2262\u20132268, 2021<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.29528","type":"journal-article","created":{"date-parts":[[2021,3,23]],"date-time":"2021-03-23T13:22:53Z","timestamp":1616505773000},"page":"2262-2268","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["<scp>pT3 N0<\/scp> Laryngeal Squamous Cell Carcinoma: Oncologic Outcomes and Prognostic Factors of Surgically Treated Patients"],"prefix":"10.1002","volume":"131","author":[{"given":"Francesco","family":"Mattioli","sequence":"first","affiliation":[{"name":"Otorhinolaryngology Head and Neck Surgery Department University Hospital of Modena  Modena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2727-0321","authenticated-orcid":false,"given":"Matteo","family":"Fermi","sequence":"additional","affiliation":[{"name":"Otorhinolaryngology Head and Neck Surgery Department University Hospital of Modena  Modena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3402-4364","authenticated-orcid":false,"given":"Giulia","family":"Molinari","sequence":"additional","affiliation":[{"name":"Otorhinolaryngology Head and Neck Surgery Department University Hospital of Modena  Modena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5294-0449","authenticated-orcid":false,"given":"Vincenzo","family":"Capriotti","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology and Head and Neck Surgery University of Trieste, Cattinara Hospital  Trieste Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriele","family":"Melegari","sequence":"additional","affiliation":[{"name":"Anesthesiology and Reanimation Department University Hospital of Modena  Modena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federica","family":"Bertolini","sequence":"additional","affiliation":[{"name":"Department of Oncology and Hematology University Hospital of Modena  Modena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa","family":"D'Angelo","sequence":"additional","affiliation":[{"name":"Radiation Oncology Unit University Hospital of Modena  Modena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giancarlo","family":"Tirelli","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology and Head and Neck Surgery University of Trieste, Cattinara Hospital  Trieste Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Livio","family":"Presutti","sequence":"additional","affiliation":[{"name":"Otorhinolaryngology Head and Neck Surgery Department University Hospital of Modena  Modena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,3,23]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004050050228"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-007-0279-z"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-014-3024-4"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.21785"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.30586"},{"key":"e_1_2_6_7_1","unstructured":"National Comprehensive Cancer Network.NCCN guidelines for head and neck cancer care. Available at:https:\/\/www.nccn.org\/professionals\/physician_gls\/pdf\/head-and-neck_blocks.pdfAccessed August 9 2020."},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1067\/mhn.2000.98756"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2007.01.010"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-40618-3"},{"key":"e_1_2_6_11_1","volume-title":"WHO Classification of Head and Neck Tumours","author":"El\u2010Naggar AK","year":"2017"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.1978.88.9.1529"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjoto.2010.11.016"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.25176"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2016.05.030"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoto.2014.1671"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoto.2016.1609"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mlg.0000236095.97947.26"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.134.4.370"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/coa.13018"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1080\/00016489.2018.1490031"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2020.104825"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200207000-00026"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.22994"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.23563"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016489.2016.1146827"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.10152"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.21085"}],"container-title":["The Laryngoscope"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lary.29528","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/lary.29528","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lary.29528","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,25]],"date-time":"2023-08-25T08:03:06Z","timestamp":1692950586000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/lary.29528"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,23]]},"references-count":27,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2021,10]]}},"alternative-id":["10.1002\/lary.29528"],"URL":"https:\/\/doi.org\/10.1002\/lary.29528","archive":["Portico"],"relation":{},"ISSN":["0023-852X","1531-4995"],"issn-type":[{"value":"0023-852X","type":"print"},{"value":"1531-4995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,3,23]]},"assertion":[{"value":"2020-10-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-03-15","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-03-23","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}