{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T13:23:27Z","timestamp":1789910607893,"version":"4.0.1"},"reference-count":27,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["UL1 TR00045"],"award-info":[{"award-number":["UL1 TR00045"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["UL1 TR002014"],"award-info":[{"award-number":["UL1 TR002014"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:sec><jats:title>Objectives\/Hypothesis<\/jats:title><jats:p>The goal of head and neck cancer surgery is the complete resection of tumor with a cuff of healthy tissue. A 5\u2010mm margin is optimal but not always achievable in the oropharynx. We aimed to identify a consensus of definition and management of close margins for human papilloma virus (HPV)\u2010associated oropharyngeal cancer without other risk factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Descriptive survey.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A survey of the American Head and Neck Society (AHNS) was conducted to evaluate the abovementioned objectives by presenting hypothetical scenarios and asking questions regarding management.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>One\u2010hundred fifty\u2010five AHNS members completed the survey (18% response rate). Close margins were defined as &lt;5\u2009mm, &lt;3\u2009mm, and &lt;1\u2009mm by 27.7%, 32.3%, and 32.3% of respondents. There was no significant difference in margin determination with experience level (<jats:italic>P<\/jats:italic>\u00a0=\u2009.186). In an HPV\u2010positive tumor with close margins, 51% chose postoperative observation. The remainder chose adjuvant radiation (22.6%), chemoradiation (1.9%), or re\u2010excision of the wound bed (19.4%). There was no association between postoperative close margin management and experience level (<jats:italic>P<\/jats:italic>\u00a0=\u2009.80).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Heterogeneity exists in the definition and management of close margins in HPV\u2010mediated oropharyngeal carcinoma (OPSCC). Establishing a standard regarding close margins in HPV\u2010mediated OPSCC may allow for the optimization of outcomes and help define best practices.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>5 <jats:italic>Laryngoscope<\/jats:italic>, 131:E2650\u2013E2654, 2021<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.29533","type":"journal-article","created":{"date-parts":[[2021,4,2]],"date-time":"2021-04-02T03:49:50Z","timestamp":1617335390000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Surgical Margin Determination in the Era of <scp>HPV<\/scp>\u2010Positive Oropharyngeal Cancer"],"prefix":"10.1002","volume":"131","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6566-8883","authenticated-orcid":false,"given":"Christopher","family":"Pool","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery The Pennsylvania State University  Hershey Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taelor","family":"Weaver","sequence":"additional","affiliation":[{"name":"Department of Medical Education The Pennsylvania State University  Hershey Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junjia","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Public Health Sciences, Division of Biostatistics and Bioinformatics The Pennsylvania State University  Hershey Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Goldenberg","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery The Pennsylvania State University  Hershey Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7783-1097","authenticated-orcid":false,"given":"Neerav","family":"Goyal","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery The Pennsylvania State University  Hershey Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,4]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2020.104883"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9610(76)90314-7"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcms.2006.04.004"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1054\/bjom.1999.0235"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(87)90095-2"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9610(05)80555-0"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1054\/ijom.2002.0313"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.25397"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2015.01.015"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2019.09.017"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.24824"},{"key":"e_1_2_5_13_1","unstructured":"National Comprehensive Cancer Network (NCCN)Head and Neck Cancers (Version 1.2020). 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