{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T18:44:21Z","timestamp":1787856261219,"version":"build-2784847793"},"reference-count":21,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2021,4,29]],"date-time":"2021-04-29T00:00:00Z","timestamp":1619654400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:sec><jats:title>Objectives\/Hypothesis<\/jats:title><jats:p>To describe the use of capillary blood gas (CBG) sampling to detect and quantify hypoventilation in infants with Robin sequence (RS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Case series with chart review at two institutions. Infants with RS presenting over a 10\u2010year period were identified using departmental databases. CBG values obtained during infancy or until airway intervention (AI) were reviewed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>From 2008 to 2018, 111 infants with RS were identified as having had been assessed and managed from birth or transfer until discharge home and having CBG data available. In most cases, CBG sampling was obtained every other day until intervention or discharge. A total of 81 (73%) infants required AI: 72 (89%) underwent mandibular distraction osteogenesis, five (6%) underwent tracheotomy, and four (5%) were discharged home with a nasopharyngeal airway. The mean PCO<jats:sub>2<\/jats:sub> at day of life (DOL) 7\u201330 for the AI group was 52.7\u2009mmHg (95% confidence interval: 51.7\u201353.7) and for the no AI group was 45.9\u2009mmHg (44.8\u201347.0; <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.0001). The mean HCO<jats:sub>3<\/jats:sub> at DOL 7\u201330 for the AI group was 29.8\u2009mEq\/L (29.4\u201330.1) and for the no AI group was 27.0\u2009mEq\/L (26.5\u201327.4; <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.0001). Receiver operating characteristic curves were created for maximum PCO<jats:sub>2<\/jats:sub> and HCO<jats:sub>3<\/jats:sub> values and cutoffs were established by optimizing a balance of sensitivity and specificity. Infants requiring AI surpassed the PCO<jats:sub>2<\/jats:sub> and HCO<jats:sub>3<\/jats:sub> cutoff at a median of DOL 9.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Among infants with RS and hypoventilation, objective measures of respiratory acidosis may be apparent by DOL 9.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>4 <jats:italic>Laryngoscope<\/jats:italic>, 131:2789\u20132794, 2021<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.29594","type":"journal-article","created":{"date-parts":[[2021,4,29]],"date-time":"2021-04-29T15:00:07Z","timestamp":1619708407000},"page":"2789-2794","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Detection of Chronic Hypoventilation Among Infants With Robin Sequence Using Capillary Blood Gas Sampling"],"prefix":"10.1002","volume":"131","author":[{"given":"James T.","family":"Kwan","sequence":"first","affiliation":[{"name":"Department of Otolaryngology \u2010 Head &amp; Neck Surgery Tufts University School of Medicine  Boston Massachusetts U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bridget E.","family":"Ebert","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2010 Head &amp; Neck Surgery University of Minnesota Medical School  Minneapolis Minnesota U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7244-3247","authenticated-orcid":false,"given":"Brianne B.","family":"Roby","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2010 Head &amp; Neck Surgery University of Minnesota Medical School  Minneapolis Minnesota U.S.A."},{"name":"Department of Otolaryngology and Facial Plastic Surgery Children's of Minnesota  Minneapolis Minnesota U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0856-3396","authenticated-orcid":false,"given":"Andrew R.","family":"Scott","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2010 Head &amp; Neck Surgery Tufts University School of Medicine  Boston Massachusetts U.S.A."},{"name":"Divisions of Pediatric Otolaryngology and Facial Plastic Surgery, Department of Otolaryngology\u2013Head and Neck Surgery Tufts Children's Hospital \u2010 Tufts Medical Center  Boston Massachusetts U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,4,29]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"37","article-title":"La chute de la base de la langue consid\u00e9r\u00e9e comme une nouvelle cause de gans la respiration naso\u2010pharyngienne","volume":"89","author":"Robin P","year":"1923","journal-title":"Bull Acad Natl Med"},{"key":"e_1_2_6_3_1","first-page":"541","article-title":"Glossoptosis due to atresia and hypotrophy of the mandible","volume":"48","author":"Robin P","year":"1934","journal-title":"Am J Dis Child"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-016-1996-8"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005176-200103000-00012"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otc.2012.03.007"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/1055665618778400"},{"key":"e_1_2_6_8_1","first-page":"1","article-title":"Polysomnography in patients with obstructive sleep apnea: an evidence\u2010based analysis","volume":"6","author":"Medical Advisory Secretariat","year":"2006","journal-title":"Ont Health Technol Assess Ser"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/lio2.137"},{"key":"e_1_2_6_10_1","volume-title":"International Classification of Sleep Disorders","author":"American Academy of Sleep Medicine","year":"2014"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.34.2.192"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.44.238.726"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-199711000-00032"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02723794"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2002.016261"},{"key":"e_1_2_6_16_1","first-page":"123","volume-title":"Acute Respiratory Care of the Neonate","author":"Debbie F","year":"2012"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.PRS.0000110323.50084.21"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1597\/07-129.1"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2015.01.035"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2010-2615"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.109.4.704"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2019-1097"}],"container-title":["The Laryngoscope"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lary.29594","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/lary.29594","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lary.29594","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T16:13:25Z","timestamp":1693239205000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/lary.29594"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4,29]]},"references-count":21,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["10.1002\/lary.29594"],"URL":"https:\/\/doi.org\/10.1002\/lary.29594","archive":["Portico"],"relation":{},"ISSN":["0023-852X","1531-4995"],"issn-type":[{"value":"0023-852X","type":"print"},{"value":"1531-4995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,4,29]]},"assertion":[{"value":"2021-01-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-04-29","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}