{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T16:29:17Z","timestamp":1783355357649,"version":"3.54.6"},"reference-count":19,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2021,5,5]],"date-time":"2021-05-05T00:00:00Z","timestamp":1620172800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2016\/01740\u20106"],"award-info":[{"award-number":["2016\/01740\u20106"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To determine the implication of the new AJCC staging system for pT classification in a cohort of patients with SCC of the lip mucosa and compare it to other oral cavity sites.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Retrospective cohort of 744 patients treated between 2002 and 2017, by the Head and Neck Surgery Department of the University of Sao Paulo.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 95 lip patients, 42 had pT upstage (58.1% of pT1 to pT2\u20103 and 50% of pT2 to pT3). Similar DFS\/OS observed for those pT1 maintained or upstaged to pT2\u20103, pT2 patients upstaged to pT3 presented worse OS (49.4% <jats:italic>versus<\/jats:italic> 92.3%, <jats:italic>P<\/jats:italic>\u00a0=\u2009.032). The comparison between lip and other mouth topographies, denoted better prognosis for pT1\u20102, but not for pT3\u20104a. Lip tumors had lower DOI, rates of perineural\/angiolymphatic invasion, nodal metastasis, recurrence, and death.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The inclusion of DOI to the new pT classification better stratifies patients with SCC of the lip mucosa upstaged to pT3 by assessing inferior OS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>3 <jats:italic>Laryngoscope<\/jats:italic>, 131:E2770\u2013E2776, 2021<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.29596","type":"journal-article","created":{"date-parts":[[2021,5,5]],"date-time":"2021-05-05T16:45:49Z","timestamp":1620233149000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Implication of the New <scp>AJCC pT<\/scp> Classification of <scp>SCC<\/scp> of the Lip Comparing With Other Oral Subsites"],"prefix":"10.1002","volume":"131","author":[{"given":"Loic Monginet","family":"Toledo","sequence":"first","affiliation":[{"name":"Head and Neck Surgery Department University of S\u00e3o Paulo Medical School  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriana Santos","family":"de Oliveira","sequence":"additional","affiliation":[{"name":"Head and Neck Surgery Department University of S\u00e3o Paulo Medical School  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2453-7158","authenticated-orcid":false,"given":"Renan Aguera","family":"Pinheiro","sequence":"additional","affiliation":[{"name":"Head and Neck Surgery Department University of S\u00e3o Paulo Medical School  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7814-757X","authenticated-orcid":false,"given":"Ana Kober Nogueira","family":"Leite","sequence":"additional","affiliation":[{"name":"Head and Neck Surgery 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