{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T02:37:21Z","timestamp":1773283041988,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2021,5,19]],"date-time":"2021-05-19T00:00:00Z","timestamp":1621382400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:sec><jats:title>Objectives\/Hypothesis<\/jats:title><jats:p>To investigate the prevalence and features of laryngopharyngeal reflux (LPR) in patients with primary burning mouth syndrome (BMS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Prospective uncontrolled study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients who visited our Departments of Otolaryngology\u2010Head and Neck and Maxillofacial surgery with BMS were prospectively recruited from September 2018 to September 2020. Patients benefited from dental, maxillofacial, otolaryngological examinations, and hypopharyngeal\u2013esophageal impedance pH\u2010monitoring (HEMII\u2010pH). Oral, pharyngeal, and laryngeal findings and symptoms were rated with Reflux Sign Assessment (RSA) and Reflux Symptom Score\u201012 (RSS\u201012). Patients were treated with a combination of diet, pantoprazole, and alginate.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>From the 81 included patients, 76 reported &gt;1 pharyngeal reflux events (93.8%), accounting for 35 (46.1%), 24 (31.6%), and 17 (22.3%) acid, mixed, and nonacid LPR, respectively. Thirty\u2010two patients had both LPR and gastroesophageal reflux disease (GERD). Thirty\u2010eight patients benefited from pepsin saliva measurement, which was positive in 86.8% of cases. The mean scores of mouth\/tongue burning, RSS\u201012, and RSA significantly improved from pre\u2010 to post\u2010treatment (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.004). At 3\u2010month post\u2010treatment, 62.5% of patients reported an improvement of mouth\/tongue burning score. Patients with both GERD and LPR reported higher baseline RSS\u201012 and RSA scores.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Acid, weakly acid, and nonacid LPR may be involved in the development of BMS. The use of an appropriate treatment considering the reflux features is associated with an improvement of symptoms and findings.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>4 <jats:italic>Laryngoscope<\/jats:italic>, 131:E2627\u2013E2633, 2021<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.29604","type":"journal-article","created":{"date-parts":[[2021,5,19]],"date-time":"2021-05-19T16:38:53Z","timestamp":1621442333000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Prevalence and Features of Laryngopharyngeal Reflux in Patients with Primary Burning Mouth Syndrome"],"prefix":"10.1002","volume":"131","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0845-0845","authenticated-orcid":false,"given":"Jerome R.","family":"Lechien","sequence":"first","affiliation":[{"name":"Reflux Study Group Laryngopharyngeal Reflux Study Group of Young\u2010Otolaryngologists of the International Federations of Oto\u2010rhino\u2010laryngological Societies (YO\u2010IFOS)  Paris France"},{"name":"Department of Otolaryngology\u2010Head and Neck Surgery, Foch Hospital, School of Medicine University Paris Saclay  Paris France"},{"name":"Department of Otolaryngology\u2010Head and Neck Surgery, CHU Saint\u2010Pierre Universit\u00e9 Libre de Bruxelles  Brussels Belgium"},{"name":"Department of Human Anatomy and Experimental Oncology, Faculty of Medicine UMONS Research Institute for Health Sciences and Technology, University of Mons (UMons)  Mons Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"St\u00e9phane","family":"Hans","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery, Foch Hospital, School of Medicine University Paris Saclay  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisa G.","family":"De Marrez","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery, Foch Hospital, School of Medicine University Paris Saclay  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Didier","family":"Dequanter","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery, CHU Saint\u2010Pierre Universit\u00e9 Libre de Bruxelles  Brussels Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandra","family":"Rodriguez","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery, CHU Saint\u2010Pierre Universit\u00e9 Libre de Bruxelles  Brussels Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vinciane","family":"Muls","sequence":"additional","affiliation":[{"name":"Reflux Study Group Laryngopharyngeal Reflux Study Group of Young\u2010Otolaryngologists of the International Federations of Oto\u2010rhino\u2010laryngological Societies (YO\u2010IFOS)  Paris 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