{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T16:03:13Z","timestamp":1760976193629,"version":"3.40.5"},"reference-count":61,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2021,5,18]],"date-time":"2021-05-18T00:00:00Z","timestamp":1621296000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:sec><jats:title>Objectives\/Hypothesis<\/jats:title><jats:p>To investigate the risk of residual tympanic membrane (TM) perforation after intratympanic (IT) steroidal treatment administered <jats:italic>via<\/jats:italic> transtympanic injection compared with trans\u2010tympanostomy tube (TyT).<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Case series, systematic review and meta analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data were retrieved from the medical files of an original cohort of all consecutive patients with sudden sensorineural hearing loss necessitating IT steroidal treatment in a tertiary medical center between January 1, 2016 and November 20, 2020. A systematic literature search of \u201cMEDLINE\u201d <jats:italic>via<\/jats:italic> \u201cPubMed,\u201d \u201cEmbase,\u201d and \u201cWeb of Science\u201d on comparable published cases was performed and meta\u2010analysis was established.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Eighteen studies describing 818 ears were included in the quantitative meta\u2010analysis in addition to a local cohort of 140 ears. The proportion of residual TM perforation was 1.11% and 1.14% (95% confidence interval: 0.01%\u20133.27% and 0.028%\u20132.38%) in the TyT and trans\u2010tympanic groups, respectively, suggesting no significant difference in residual TM perforation risk between these techniques.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>IT steroid therapy <jats:italic>via<\/jats:italic> trans\u2010TyT is not associated with more residual perforations than IT steroid therapy <jats:italic>via<\/jats:italic> transtympanic injections.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>NA <jats:italic>Laryngoscope<\/jats:italic>, 131:E2583\u2013E2591, 2021<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.29609","type":"journal-article","created":{"date-parts":[[2021,5,18]],"date-time":"2021-05-18T11:41:05Z","timestamp":1621338065000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Residual Perforation Risk Assessment of Intratympanic Steroids <i>via<\/i> Tympanostomy Tube Versus Transtympanic Injections"],"prefix":"10.1002","volume":"131","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9266-6392","authenticated-orcid":false,"given":"Liam","family":"Simani","sequence":"first","affiliation":[{"name":"Department of Otolaryngology Head, Neck and Maxillofacial Surgery Tel Aviv Sourasky Medical Center, Sackler School of Medicine, Tel Aviv University  Tel Aviv 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