{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T15:59:16Z","timestamp":1791907156784,"version":"4.3.4"},"reference-count":19,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2021,5,7]],"date-time":"2021-05-07T00:00:00Z","timestamp":1620345600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:sec><jats:title>Objectives\/Hypothesis<\/jats:title><jats:p>The present study aimed to investigate the efficacy of transarterial embolization (TAE) for bleeding in patients with head and neck cancer (HNC) and to evaluate the prognostic factors after TAE.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study design<\/jats:title><jats:p>Outcome study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This retrospective study included 31 consecutive patients (27 men and 4 women; median age, 61\u2009years) who presented uncontrollable hemorrhage associated with HNC and underwent emergency TAE at our institution during a 10\u2010year period (January 2011\u2013December 2020). This corresponded to 40 TAE procedures, including 27 cases with an unstable status (circulatory and\/or respiratory insufficiency) and 10 cases with carotid blowout syndrome. The technical success rate and adverse events were analyzed on a per\u2010procedure basis. The rebleeding and overall survival (OS) rates were analyzed on a per\u2010patient basis, and the factors related to OS were evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The technical success rate was 100%. As an adverse event, cerebral infarction was found in three cases with carotid blowout syndrome. The rebleeding rate at 30\u2009days after TAE and in the follow\u2010up period (range, 9\u20133,004\u2009days) was 17.2% and 35.5%, respectively. The median survival time was 263\u2009days (95% confidence interval: 124.0\u2013402.0\u2009days). In the log\u2010rank test, complete remission (CR) of the primary cancer at the time of the first TAE was identified as a significant influencing factor of survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>TAE is effective for the treatment of hemorrhage associated with HNC even in patients with an unstable status. Patients with CR can gain a long life span.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>4 <jats:italic>Laryngoscope<\/jats:italic>, 131:E2777\u2013E2783, 2021<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.29611","type":"journal-article","created":{"date-parts":[[2021,5,8]],"date-time":"2021-05-08T22:48:04Z","timestamp":1620514084000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Transarterial Embolization for Bleeding in Patients with Head and Neck Cancer: Who Benefits?"],"prefix":"10.1002","volume":"131","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5080-2333","authenticated-orcid":false,"given":"Shohei","family":"Chatani","sequence":"first","affiliation":[{"name":"Department of Diagnostic and Interventional Radiology Aichi Cancer Center Hospital  Nagoya Aichi Japan"},{"name":"Department of Radiology Shiga University of Medical Science  Otsu Shiga Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yozo","family":"Sato","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Radiology Aichi Cancer Center Hospital  Nagoya Aichi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinichi","family":"Murata","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Radiology Aichi Cancer Center Hospital  Nagoya Aichi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takaaki","family":"Hasegawa","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Radiology Aichi Cancer Center Hospital  Nagoya Aichi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryota","family":"Tsukii","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Radiology Aichi Cancer Center Hospital  Nagoya Aichi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyohei","family":"Nagasawa","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Radiology Aichi Cancer Center Hospital  Nagoya Aichi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masanori","family":"Machida","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Radiology Aichi Cancer Center Hospital  Nagoya Aichi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Terutaka","family":"Yoshihara","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Radiology Aichi Cancer Center Hospital  Nagoya Aichi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hidekazu","family":"Yamaura","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Radiology Aichi Cancer Center Hospital  Nagoya Aichi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuhiro","family":"Hanai","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery Aichi Cancer Center Hospital  Nagoya Aichi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keitaro","family":"Matsuo","sequence":"additional","affiliation":[{"name":"Division of Cancer Epidemiology and Prevention Aichi Cancer Center Research Institute  Nagoya Aichi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshitaka","family":"Inaba","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Radiology Aichi Cancer Center Hospital  Nagoya Aichi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,5,7]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00270-004-0130-5"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-007-0234-y"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2009.09.031"},{"key":"e_1_2_6_5_1","first-page":"843","article-title":"Endovascular therapy for the carotid blowout syndrome in head and neck surgical patients: diagnostic and managerial considerations","volume":"17","author":"Chaloupka JC","year":"1996","journal-title":"AJNR Am J Neuroradiol"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2015.12.047"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.2147\/CMAR.S180164"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.9-5-561"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1997.01900010017002"},{"key":"e_1_2_6_10_1","unstructured":"Common Terminology Criteria for Adverse Events v5.0 (CTCAE) 2017. 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