{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T17:48:33Z","timestamp":1792000113191,"version":"4.4.0"},"reference-count":23,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2021,6,4]],"date-time":"2021-06-04T00:00:00Z","timestamp":1622764800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives\/Hypothesis<\/jats:title>\n                    <jats:p>To investigate whether there is an impact of obesity and overweight on the clinical findings and therapeutic responses of patients with laryngopharyngeal reflux (LPR).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design<\/jats:title>\n                    <jats:p>Prospective uncontrolled.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients with LPR\u2010related symptoms and positive LPR diagnosis at the hypopharyngeal\u2010esophageal multichannel intraluminal impedance pH\u2010monitoring (HEMII\u2010pH) were recruited from December 2017 to December 2020. Patients were treated with a combination of diet, proton pump inhibitors, and alginate for 3 to 6\u2009months. The following outcomes were studied according to the weight of patients: HEMII\u2010pH, gastrointestinal endoscopy features, symptoms, findings, and therapeutic response.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 262 patients completed the study, accounting for 134, 85, and 43 patients with normal weight (body mass index [BMI] &lt;25), overweight (BMI\u00a0=\u00a025\u201329.99), and obesity (BMI &gt;30). Obese patients reported significant higher prevalence of gastroesophageal reflux disease (GERD), acid LPR, and a more severe LPR disease regarding the number of pharyngeal reflux events, reflux symptom score (RSS), and reflux sign assessment (RSA). RSS and RSA scores significantly improved from baseline to 3\u2010month posttreatment irrespective of the patient weight group. Symptoms and signs continued to improve from 3 to 6\u2010month posttreatment only in patients with a normal weight.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Obesity is associated with a more severe LPR disease and a higher proportion of GERD and acid LPR. Obese LPR patients may require more frequently PPI\u2010therapy regarding the higher prevalence of GERD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Level of Evidence<\/jats:title>\n                    <jats:p>\n                      3\n                      <jats:italic>Laryngoscope<\/jats:italic>\n                      , 131:E2742\u2013E2748, 2021\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/lary.29676","type":"journal-article","created":{"date-parts":[[2021,6,4]],"date-time":"2021-06-04T11:21:30Z","timestamp":1622805690000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Laryngopharyngeal Reflux Disease is More Severe in Obese Patients: A Prospective Multicenter Study"],"prefix":"10.1002","volume":"131","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0845-0845","authenticated-orcid":false,"given":"Jerome R.","family":"Lechien","sequence":"first","affiliation":[{"name":"Research Committee Laryngopharyngeal Reflux Study Group of Young\u2010Otolaryngologists of the International Federations of Oto\u2010rhino\u2010laryngological Societies (YO\u2010IFOS)  Paris France"},{"name":"Department of Otolaryngology\u2010Head and Neck Surgery, Foch Hospital, School of Medicine University Paris Saclay  Paris France"},{"name":"Department of Otolaryngology\u2010Head and Neck Surgery, CHU Saint\u2010Pierre Universit\u00e9 Libre de Bruxelles  Brussels Belgium"},{"name":"Department of Human Anatomy and Experimental Oncology, Faculty of Medicine, UMONS Research Institute for Health Sciences and Technology University of Mons (UMons)  Mons Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois","family":"Bobin","sequence":"additional","affiliation":[{"name":"ENT Department Elsan Polyclinic  Poitiers France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vinciane","family":"Muls","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, CHU Saint\u2010Pierre Universit\u00e9 Libre de Bruxelles  Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sven","family":"Saussez","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery, CHU Saint\u2010Pierre Universit\u00e9 Libre de Bruxelles  Brussels Belgium"},{"name":"Department of Human Anatomy and Experimental Oncology, Faculty of Medicine, UMONS Research Institute for Health Sciences and Technology University of Mons (UMons)  Mons Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phane","family":"Hans","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery, Foch Hospital, School of Medicine University Paris Saclay  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,6,4]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599819827488"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoto.2017.1454"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/coa.13269"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-019-05482-w"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12901-015-0020-2"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.28482"},{"key":"e_1_2_8_8_1","first-page":"41","article-title":"Focus on gastroesophageal reflux (GER) and laryngopharyngeal reflux(LPR): new pragmatic insights in clinical practice","volume":"32","author":"Gelardi M","year":"2018","journal-title":"J Biol Regul Homeost Agents."},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.14651"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13304-018-0579-4"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v25.i33.4805"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.MLG.0000162656.05715.57"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11605-011-1741-1"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1177\/01945998211029831"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004836-198606001-00008"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/coa.13722"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-019-05711-2"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.28017"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1177\/0003489419888947"},{"key":"e_1_2_8_20_1","unstructured":"World Health Organization.2018.Obesity and Overweight. 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