{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T11:43:13Z","timestamp":1772797393908,"version":"3.50.1"},"reference-count":26,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,6,14]],"date-time":"2021-06-14T00:00:00Z","timestamp":1623628800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>To compare the results of immediate endoscopic dacryocystorhinostomy (En\u2010DCR) and delayed En\u2010DCR in the treatment of new\u2010onset acute dacryocystitis (AD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>This report describes a prospective randomized controlled interventional case series.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Between April 2009 and May 2019, 176 adults presenting at a tertiary eye care center with new\u2010onset AD manifesting within the last 48\u2009hours were randomized into two groups. Altogether, 160 patients (48 male, 112 female) were included in this study, with a median age of 52.8\u2009years (range: 18\u201382). Patients in group A underwent urgent En\u2010DCR, although those in group B underwent a delayed En\u2010DCR after 2 to 5\u2009days of systematic antibiotic treatment. Variables compared between these two groups included the time for resolution of acute external inflammation, free lacrimal passage reconstruction (LPR) success rates, and complication rates.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Postoperative data were collected from 86 patients in group A and 74 patients in group B. Patients that underwent immediate En\u2010DCR exhibited a quicker resolution of acute inflammation (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.05). Patients that underwent delayed surgery experienced compilations of acute inflammation, with 10 ultimately developing skin fistulization and 4 exhibiting orbital cellulitis before surgery. The success rate of LPR at 12\u2009months after surgery was higher in group A (81\/86 94.2%) relative to group B (62\/74 83.8%; <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Immediate En\u2010DCR is associated with quicker disease resolution and a higher long\u2010term success rate, although reducing the incidence of complications including skin fistulization and the spread of infection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>3 <jats:italic>Laryngoscope<\/jats:italic>, 132:278\u2013283, 2022<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.29693","type":"journal-article","created":{"date-parts":[[2021,6,14]],"date-time":"2021-06-14T13:42:40Z","timestamp":1623678160000},"page":"278-283","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Immediate Endoscopic Dacryocystorhinostomy in Patients With New Onset Acute Dacryocystitis"],"prefix":"10.1002","volume":"132","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0836-9692","authenticated-orcid":false,"given":"Bo","family":"Yu","sequence":"first","affiliation":[{"name":"Department of Orbital and Oculoplastic Surgery Eye Hospital of Wenzhou Medical University  Wenzhou Zhejiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yunhai","family":"Tu","sequence":"additional","affiliation":[{"name":"Department of Orbital and Oculoplastic Surgery Eye Hospital of Wenzhou Medical University  Wenzhou Zhejiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guangming","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Orbital and Oculoplastic Surgery Eye Hospital of Wenzhou Medical University  Wenzhou Zhejiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huifeng","family":"Hong","sequence":"additional","affiliation":[{"name":"Eye Hospital of Wenzhou Medical University  Wenzhou Zhejiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wencan","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Orbital and Oculoplastic Surgery Eye Hospital of Wenzhou Medical University  Wenzhou Zhejiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,6,14]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.3109\/08820538.2013.833269"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/00002341-199303000-00005"},{"key":"e_1_2_7_4_1","first-page":"243","article-title":"The outcomes of surgical treatment in fistulous dacryocystitis","volume":"17","author":"Ari S","year":"2013","journal-title":"Eur Rev Med Pharmacol 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