{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T14:33:02Z","timestamp":1777732382620,"version":"3.51.4"},"reference-count":23,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2021,6,23]],"date-time":"2021-06-23T00:00:00Z","timestamp":1624406400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:sec><jats:title>Objectives\/Hypothesis<\/jats:title><jats:p>Surgical interventions for epistaxis management in hereditary hemorrhagic telangiectasia (HHT) demonstrate short\u2010term success and require repeated procedures for disease control. Although electrocautery and\/or laser photocoagulation (C\u2009\u00b1\u2009L) are most frequently performed, sodium tetradecyl sclerotherapy (STS) is emerging as a promising newer treatment. We hypothesized that in a 24\u2010month time period, STS would require fewer treatments than C\u2009\u00b1\u2009L to maintain epistaxis severity within the mild range.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Retrospective study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively assessed 67 patients with HHT with moderate and severe epistaxis that were treated periodically with C\u2009\u00b1\u2009L (34 patients) versus STS (33 patients). The primary outcome was the number of procedures needed to maintain the epistaxis severity score (ESS) as mild. Secondary outcomes assessed for differences in postoperative complications, hemoglobin levels, iron stores, hematologic support, and quality\u2010of\u2010life (QoL) scores.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>To maintain ESS in the mild range, 1.6 STS procedures (range, 1\u20134) were performed versus 3.6 C\u2009\u00b1\u2009L procedures (range, 1\u20138) (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.003). Significant postoperative differences included reduction in nasal crusting (3% vs. 32%, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.001), foul odor (3% vs. 35%, <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001), and septal perforation (3% vs. 29%, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.006) after STS. There were no significant differences between the two treatments in hemoglobin levels, iron stores, hematologic support, or QoL scores.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>STS is able to attain satisfactory epistaxis control with significantly fewer procedures and lower postoperative complications than C\u2009\u00b1\u2009L. STS should be considered as the initial surgical intervention for epistaxis in patients with HHT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>4 <jats:italic>Laryngoscope<\/jats:italic>, 132:920\u2013925, 2022<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.29701","type":"journal-article","created":{"date-parts":[[2021,6,23]],"date-time":"2021-06-23T11:14:50Z","timestamp":1624446890000},"page":"920-925","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Sclerotherapy Versus Cautery\/Laser Treatment for Epistaxis in Hereditary Hemorrhagic Telangiectasia"],"prefix":"10.1002","volume":"132","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4723-6681","authenticated-orcid":false,"given":"Troy D.","family":"Woodard","sequence":"first","affiliation":[{"name":"Head and Neck Institute, Cleveland Clinic Department of Otolaryngology\u2010Head and Neck Surgery  Cleveland Ohio U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathleen B.","family":"Yappel\u2010Sinkko","sequence":"additional","affiliation":[{"name":"Head and Neck Institute, Cleveland Clinic Department of Otolaryngology\u2010Head and Neck Surgery  Cleveland Ohio U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaofeng","family":"Wang","sequence":"additional","affiliation":[{"name":"Lerner Research Institute, Cleveland Clinic Department of Quantitative Health Sciences  Cleveland Ohio U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keith R.","family":"McCrae","sequence":"additional","affiliation":[{"name":"Taussig Cancer Institute, Cleveland Clinic Department of Hematology and Medical Oncology  Cleveland Ohio U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5742-4774","authenticated-orcid":false,"given":"Joseph G.","family":"Parambil","sequence":"additional","affiliation":[{"name":"Respiratory Institute, Cleveland Clinic Department of Pulmonary Medicine  Cleveland Ohio 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