{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T13:51:40Z","timestamp":1779371500521,"version":"3.53.1"},"reference-count":14,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,6,26]],"date-time":"2021-06-26T00:00:00Z","timestamp":1624665600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives\/Hypothesis<\/jats:title>\n                    <jats:p>To demonstrate that a group of patients who are not considered candidates for organ preservation can achieve organ preservation through neoadjuvant chemotherapy + surgery and to determine if there are differences regarding organ preservation, disease\u2010free survival (DFS), overall survival (OS), and cancer\u2010specific survival (CSS) after comparing such group with another one undergoing standard treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients with laryngeal cancer were retrospectively analyzed and divided into two groups. Group A included patients who were initially treated with supracricoid laryngectomy. Group B included patients with T3N0 glottic squamous cell carcinoma with arytenoid fixation. Patients were offered neoadjuvant chemotherapy. Both groups underwent bilateral selective neck dissection of lymph nodes (II\u2013V) and intentional search of the Delphian lymph nodes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Thirty\u2010four patients were assigned to group A of surgery alone, and 16 patients were included in group B of induction chemotherapy. No statistical differences were found regarding sex, tumor localization, histological diagnosis, TNM staging, recurrence, or organ preservation. DFS, OS, and CSS at 60\u2009months were the same in both groups. No statistical differences were found when comparing induction versus noninduction groups according to the T\u2010stage in DFS, OS, and CSS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Neoadjuvant chemotherapy allows to perform conservative surgery in patients with poor functional prognosis or who are not good candidates for organ preservation at first. We could perform safe surgery, and there was no more recurrence. Hence DFS is not modified (i.e., there was no more recurrence); consequently, OS and CSS are not affected. Neoadjuvant chemotherapy plus supracricoid partial laryngectomy\u2010cricohyoidoepiglottopexy is an oncologically safe procedure that preserves basic functions such as breathing, phonation, and swallowing.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Level of Evidence<\/jats:title>\n                    <jats:p>\n                      3\n                      <jats:italic>Laryngoscope<\/jats:italic>\n                      , 132:156\u2013162, 2022\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/lary.29713","type":"journal-article","created":{"date-parts":[[2021,6,26]],"date-time":"2021-06-26T08:53:07Z","timestamp":1624697587000},"page":"156-162","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Supracricoid Partial Laryngectomy With and Without Neoadjuvant Chemotherapy in Glottic Cancer"],"prefix":"10.1002","volume":"132","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1862-4036","authenticated-orcid":false,"given":"Kuauhyama","family":"Luna\u2010Ortiz","sequence":"first","affiliation":[{"name":"Department of Head and Neck Surgery Instituto Nacional de Cancerolog\u00eda  Mexico City Mexico"},{"name":"Department of General Surgery (Head and Neck) Hospital Manuel Gea Gonzalez  Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy","family":"Reynoso\u2010Noveron","sequence":"additional","affiliation":[{"name":"Research Department Instituto Nacional de Cancerolog\u00eda  Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis C.","family":"Zacarias\u2010Ramon","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery Instituto Nacional de Cancerolog\u00eda  Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel","family":"Alvarez\u2010Avitia","sequence":"additional","affiliation":[{"name":"Department of Clinical Oncology Instituto Nacional de Cancerolog\u00eda  Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zelik","family":"Luna\u2010Peteuil","sequence":"additional","affiliation":[{"name":"General Medicine Universitatea de Medicin\u00e2 \u0219i Farmacie Grigore T. Popa  Ia\u0219i Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dorian Y.","family":"Garcia\u2010Ortega","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology Instituto Nacional de Cancerolog\u00eda  Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,6,26]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"471","article-title":"Clinical trial of cisplatin and 5\u2010FU infusion as initial treatment for advanced squamous cell carcinoma of the head and neck","volume":"66","author":"Kish J","year":"1982","journal-title":"Cancer Treat Rep"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199106133242402"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa031317"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0347(199810)20:7<595::AID-HED3>3.0.CO;2-K"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2017.75.7385"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-014-3024-4"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2013.31.15_suppl.e17031"},{"key":"e_1_2_6_9_1","first-page":"271","article-title":"Induction chemotherapy followed by supracricoid partial laryngectomy (SCPL) with cricohyoidoepiglottopexy (CHEP) in T3N0 arytenoid fixation\u2010related glottic cancer","volume":"12","author":"Luna\u2010Ortiz K","year":"2016","journal-title":"B\u2010ENT"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa071028"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa070956"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2007.14.8841"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7819-7-101"},{"key":"e_1_2_6_14_1","first-page":"329","article-title":"Demographic data of larynx cancer at the Instituto Nacional de Cancerologya in Mexico City","volume":"77","author":"Herrera\u2010Gomez A","year":"2009","journal-title":"Cir Cir"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12070-021-02470-7"}],"container-title":["The Laryngoscope"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lary.29713","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/lary.29713","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lary.29713","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T08:52:00Z","timestamp":1762591920000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/lary.29713"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,26]]},"references-count":14,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,1]]}},"alternative-id":["10.1002\/lary.29713"],"URL":"https:\/\/doi.org\/10.1002\/lary.29713","archive":["Portico"],"relation":{},"ISSN":["0023-852X","1531-4995"],"issn-type":[{"value":"0023-852X","type":"print"},{"value":"1531-4995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,6,26]]},"assertion":[{"value":"2021-04-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-06-21","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-06-26","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}