{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T08:53:34Z","timestamp":1762592014739,"version":"build-2065373602"},"reference-count":42,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,7,10]],"date-time":"2021-07-10T00:00:00Z","timestamp":1625875200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The histological grade of parotid gland carcinoma (PGC) is an important prognostic factor; however, the diagnosis prior to treatment has been challenging to make. This study aimed to investigate whether the pretreatment clinical findings, including hematological inflammatory, nutritional, and immune markers, could predict the histological grade of PGC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design<\/jats:title>\n                    <jats:p>Retrospective study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We retrospectively enrolled 111 patients with PGC and evaluated the correlation between histological grade and pretreatment clinical findings such as age, sex, tumor staging, facial nerve paralysis, pain or tenderness, adhesion to the surrounding tissues or tumor immobility, and hematological markers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Sixty patients (54%) were diagnosed with histological high\u2010grade PGC. Univariate analysis revealed that age, T classification, N classification, TNM stage, facial nerve paralysis, adhesion\/immobility, C\u2010reactive protein (CRP), and CRP\u2010to\u2010albumin ratio (CAR) were significant predictors of PGC histological grade. On multivariate analysis, high T classification (T3, 4), high N classification (\u22651), and elevated CRP (\u22650.22\u2009mg\/dL) were independent predictors of high\u2010grade PGC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Pretreatment T classification, N classification, and CRP are significant predictors of the histological grading of PGC. Our results are useful for treatment planning and obtaining appropriate informed consent from the patients before treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Level of Evidence<\/jats:title>\n                    <jats:p>\n                      4\n                      <jats:italic>Laryngoscope<\/jats:italic>\n                      , 132:96\u2013102, 2022\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/lary.29728","type":"journal-article","created":{"date-parts":[[2021,7,10]],"date-time":"2021-07-10T06:14:21Z","timestamp":1625897661000},"page":"96-102","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Pretherapeutic Predictive Factors for Histological High\u2010Grade Parotid Gland Carcinoma"],"prefix":"10.1002","volume":"132","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6206-6214","authenticated-orcid":false,"given":"Takuya","family":"Mikoshiba","sequence":"first","affiliation":[{"name":"Department of Otolaryngology, Head and Neck Surgery Keio University School of Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyuki","family":"Ozawa","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Head and Neck Surgery Keio University School of Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshihiro","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck Surgery International University of Health and Welfare School of Medicine  Narita Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miho","family":"Kawaida","sequence":"additional","affiliation":[{"name":"Department of Pathology Keio University School of Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariko","family":"Sekimizu","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Head and Neck Surgery Keio University School of Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shin","family":"Saito","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Head and Neck Surgery Keio University School of Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keisuke","family":"Yoshihama","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Head and Neck Surgery Keio University School of Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shintaro","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Head and Neck Surgery Keio University School of Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryoto","family":"Nagai","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Head and Neck Surgery Keio University School of Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yorihisa","family":"Imanishi","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck Surgery International University of Health and Welfare School of Medicine  Narita Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaori","family":"Kameyama","sequence":"additional","affiliation":[{"name":"Department of Pathology Keio University School of Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaoru","family":"Ogawa","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Head and Neck Surgery Keio University School of Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,7,10]]},"reference":[{"doi-asserted-by":"publisher","key":"e_1_2_10_2_1","DOI":"10.1016\/j.jcms.2013.02.003"},{"doi-asserted-by":"publisher","key":"e_1_2_10_3_1","DOI":"10.1038\/sj.bjc.6990501"},{"doi-asserted-by":"publisher","key":"e_1_2_10_4_1","DOI":"10.1177\/0194599816659257"},{"doi-asserted-by":"publisher","key":"e_1_2_10_5_1","DOI":"10.1002\/cncr.20186"},{"unstructured":"NCCN clinical practice guidelines in oncology (NCCN Guidelines\u00ae): head and neck cancers Version 3 2021. 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