{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T15:30:40Z","timestamp":1784647840849,"version":"3.55.0"},"reference-count":75,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2021,7,7]],"date-time":"2021-07-07T00:00:00Z","timestamp":1625616000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:sec><jats:title>Objective(s)<\/jats:title><jats:p>To describe cochlear implantation (CI) outcomes, with speech perception, auditory, language, and parent\u2010reported auditory and speech behaviors, in children with an enlarged vestibular aqueduct (EVA) and incomplete partition type 2 (IP\u2010II) and compare to control children without inner ear malformations (IEMs) and to determine cerebrospinal fluid gusher rates and effect on outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Systematic review and meta\u2010analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>MEDLINE, Embase, Cochrane, and CINAHL databases were searched from inception to February 2020. Studies reporting relevant outcomes in children with EVA or EVA\u2009+\u2009IP\u2010II and controls without IEMs undergoing CI were included. Mean differences in speech perception, auditory, and language scores between cases and controls were meta\u2010analyzed. Gusher rates were determined by proportion meta\u2010analyses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 214 identified articles, 42 met inclusion criteria, evaluating 775 cases and 2,191 controls. Of \u2013cases, 578 (74.6%) had EVA and 197 (25.4%) had EVA\u2009+\u2009IP\u2010II. Cases showed a significant improvement in speech perception, auditory and language performance, comparable to controls. Parent\u2010reported auditory and speech production behaviors outcomes were positive among cases and comparable to controls. Pooled gusher proportions in EVA and EVA\u2009+\u2009IP\u2010II cases were 27.7% (95% CI: 17.6\u201339.1) and 48.6% (95% CI: 28.6\u201369.0), respectively, with a proportion difference of 20.9% (95% CI: 11.0\u201330.1). Gusher occurrence did not impact speech perception or language outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Outcomes in children with EVA or EVA\u2009+\u2009IP\u2010II undergoing CI are favorable and largely comparable to outcomes in children with hearing loss undergoing CI without IEMs. Intraoperative gusher is more prevalent among children with EVA\u2009+\u2009IP\u2010II as compared to iEVA. Gusher does not influence speech perception and language development outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>NA <jats:italic>Laryngoscope<\/jats:italic>, 132:1459\u20131472, 2022<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.29742","type":"journal-article","created":{"date-parts":[[2021,7,7]],"date-time":"2021-07-07T19:03:38Z","timestamp":1625684618000},"page":"1459-1472","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Cochlear Implantation in Pediatric Patients With Enlarged Vestibular Aqueduct: A Systematic Review"],"prefix":"10.1002","volume":"132","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8999-5443","authenticated-orcid":false,"given":"Liliya","family":"Benchetrit","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery Boston University Medical Center  Boston Massachusetts 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