{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T18:09:22Z","timestamp":1767982162852,"version":"3.49.0"},"reference-count":19,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,7,29]],"date-time":"2021-07-29T00:00:00Z","timestamp":1627516800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Previous studies examining changes in central sleep apnea (CSA) following adenotonsillectomy (T&amp;A) performed for obstructive sleep apnea (OSA) in children have been limited by sample size and analysis of only certain populations. The aim of this study was to determine whether CSA improves following T&amp;A and what factors mediate this change.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a retrospective case series from 1994 to 2020 of children undergoing primary T&amp;A for OSA (obstructive apnea\u2010hypopnea index \u22651) with CSA (central apnea index [CAI] \u22651) and preoperative and postoperative polysomnograms within 12\u2009months of T&amp;A. Polysomnograms were analyzed for improvement in CSA, defined as: 1) if preoperative CAI &gt;5, a postoperative CAI &lt;5; or 2) if preoperative CAI &lt;5, a postoperative CAI &lt;1.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>One hundred twenty\u2010three patients were included. Median age was 5.5\u2009years (interquartile range, 2.9\u20138.4). Most patients were overweight\/obese (58.5%). Nineteen (15.4%) had a syndromic condition. Preoperative CAI was \u22655 in 21 (17.1%) patients. CAI significantly decreased following T&amp;A (preoperative 2.1, postoperative 0.4; <jats:italic>P<\/jats:italic>\u00a0&lt;\u2009.001). Thirty\u2010two (26.0%) patients had CSA postoperatively. Improvement in the microarousal index and older age were significantly associated with improvement in CSA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>T&amp;A led to resolution of CSA in most children with OSA. Improvement in the microarousal index was associated with improvement in CAI, suggesting that preoperative central apneas may be postarousal and thus resolve following T&amp;A.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>4 <jats:italic>Laryngoscope<\/jats:italic>, 132:478\u2013484, 2022<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.29784","type":"journal-article","created":{"date-parts":[[2021,7,29]],"date-time":"2021-07-29T13:49:32Z","timestamp":1627566572000},"page":"478-484","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Improvement in Central Sleep Apnea Following Adenotonsillectomy in Children"],"prefix":"10.1002","volume":"132","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2461-2904","authenticated-orcid":false,"given":"Ryan T.","family":"Judd","sequence":"first","affiliation":[{"name":"University of Chicago Pritzker School of Medicine  Chicago Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Babak","family":"Mokhlesi","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Section of Pulmonary and Critical Care University of Chicago Medicine  Chicago Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7197-9290","authenticated-orcid":false,"given":"Andrea","family":"Shogan","sequence":"additional","affiliation":[{"name":"Department of Surgery, Section of Otolaryngology Head &amp; Neck Surgery University of Chicago Medicine  Chicago Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fuad M.","family":"Baroody","sequence":"additional","affiliation":[{"name":"Department of Surgery, Section of Otolaryngology Head &amp; Neck Surgery University of Chicago Medicine  Chicago Illinois USA"},{"name":"Department of Pediatrics University of Chicago Medicine  Chicago Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,7,29]]},"reference":[{"key":"e_1_2_5_2_1","volume-title":"The AASM Manual for Scoring of Sleep and Associated Events: Rules, Terminology and Technical Specifications, Version 2.6","author":"Berry RB","year":"2020"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.125.3.872"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.21469"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2016.07.016"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prrv.2018.07.005"},{"key":"e_1_2_5_7_1","first-page":"477","article-title":"Respiration during sleep in children","volume":"128","author":"Carskadon MA","year":"1978","journal-title":"West J Med"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2869.2009.00766.x"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/zsz044"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599811428118"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2016.05.018"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599815587877"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.24469"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anl.2019.01.001"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1439-054x.2001.01148.x"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/pr.2016.43"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2005-1067"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200912-1930OC"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1215881"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599818801757"}],"container-title":["The Laryngoscope"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lary.29784","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/lary.29784","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lary.29784","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T06:42:24Z","timestamp":1692600144000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/lary.29784"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7,29]]},"references-count":19,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022,2]]}},"alternative-id":["10.1002\/lary.29784"],"URL":"https:\/\/doi.org\/10.1002\/lary.29784","archive":["Portico"],"relation":{},"ISSN":["0023-852X","1531-4995"],"issn-type":[{"value":"0023-852X","type":"print"},{"value":"1531-4995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,7,29]]},"assertion":[{"value":"2021-04-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-07-20","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-07-29","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}