{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T02:44:47Z","timestamp":1768272287557,"version":"3.49.0"},"reference-count":34,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,8,9]],"date-time":"2021-08-09T00:00:00Z","timestamp":1628467200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>We examined rates of upper aerodigestive tract (UADT) procedures in a multi\u2010institutional cohort of neonates with esophageal atresia\/tracheoesophageal fistula (EA\/TEF) to estimate secondary UADT pathology.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective cohort study was performed using a previously\u2010validated population of patients with EA\/TEF within the Pediatric Health Information System (PHIS) between 2007 and 2015. ICD\u20109\/10\u2010CM codes for aerodigestive procedures were examined from 2007 to 2020: 1) diagnostic direct laryngoscopy and\/or bronchoscopy (DLB), 2) DLB with intervention, 3) tracheostomy, 4) gastrostomy, 5) fundoplication, 6) aortopexy, 7) laryngotracheoplasty, and 8) esophageal dilation. Associations between procedures and demographics, length of gestation, and weight were estimated using generalized linear mixed models.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We identified 2,509 patients with EA\/TEF from 47 hospitals, 56.7% male and 43.3% female. Median length of stay for the first admission was 24\u2009days (interquartile range: 12\u201355). Of these patients, 1,943 (77.4%) had at least one aerodigestive procedure within 14 admissions. Specifically, 1,635 (65.2%) underwent diagnostic DLB, 85 (3.4%) DLB with intervention, 167 (6.7%) tracheostomy, 1,043 (41.2%) gastrostomy, 211 (11.0%) fundoplication, 52 (2.1%) aortopexy, 161 (6.4%) laryngotracheoplasty, and 207 (8.3%) esophageal dilation. Preterm gestation increased odds of tracheostomy (adjusted odds ratio (OR) 2.4, 95% confidence interval (CI) 1.5\u20133.7), gastrostomy (OR 2.1, CI 1.7\u20132.7), fundoplication (OR 1.7, CI 1.1\u20132.4), aortopexy (OR 5.8, CI 2.1\u201316.1), and esophageal dilation (OR 2.0, CI 1.4\u20133.0). Very low birth weight (&lt;1,500\u2009g) increased odds of gastrostomy (OR 2.5, CI 1.6\u20133.8).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Patients with EA\/TEF frequently have aerodigestive sequelae. This work helps quantify aerodigestive needs in neonates with EA\/TEF, suggesting early otolaryngology evaluation in their care.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>3 <jats:italic>Laryngoscope<\/jats:italic>, 132:695\u2013700, 2022<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.29798","type":"journal-article","created":{"date-parts":[[2021,8,9]],"date-time":"2021-08-09T12:23:55Z","timestamp":1628511835000},"page":"695-700","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Quantifying Upper Aerodigestive Sequelae in Esophageal Atresia\/Tracheoesophageal Fistula Neonates"],"prefix":"10.1002","volume":"132","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4764-2927","authenticated-orcid":false,"given":"Kelli","family":"Patterson","sequence":"first","affiliation":[{"name":"Center for Surgical Outcomes Research Abigail Wexner Research Institute at Nationwide Children's Hospital  Columbus Ohio U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tariku J.","family":"Beyene","sequence":"additional","affiliation":[{"name":"Center for Surgical Outcomes Research Abigail Wexner Research Institute at Nationwide Children's Hospital  Columbus Ohio U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lindsey","family":"Asti","sequence":"additional","affiliation":[{"name":"Center for Surgical Outcomes Research Abigail Wexner Research Institute at Nationwide Children's Hospital  Columbus Ohio U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdulrahman","family":"Althubaiti","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery Nationwide Children's Hospital and The Ohio State University  Columbus Ohio U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meredith","family":"Lind","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery Nationwide Children's Hospital and The Ohio State University  Columbus Ohio U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6857-2086","authenticated-orcid":false,"given":"Prasanth","family":"Pattisapu","sequence":"additional","affiliation":[{"name":"Center for Surgical Outcomes Research Abigail Wexner Research Institute at Nationwide Children's Hospital  Columbus Ohio U.S.A."},{"name":"Department of Otolaryngology\u2014Head and Neck Surgery Nationwide Children's Hospital and The Ohio State University  Columbus Ohio U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,8,9]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2017.12.025"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2014.03.016"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2005.11.009"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.24982"},{"key":"e_1_2_6_6_1","first-page":"476","article-title":"Long\u2010term outcomes of patients with tracheoesophageal fistula\/esophageal atresia: survey results from tracheoesophageal fistula\/esophageal atresia online communities","volume":"26","author":"Acher CW","year":"2016","journal-title":"Eur J Pediatr Surg"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2014.00039"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13052-017-0396-2"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0030-1249610"},{"key":"e_1_2_6_10_1","first-page":"161","article-title":"Infants born with esophageal atresia with or without Tracheo\u2010esophageal fistula: short\u2010 and long\u2010term outcomes","volume":"20","author":"Leibovitch L","year":"2018","journal-title":"Isr Med Assoc J"},{"key":"e_1_2_6_11_1","unstructured":"ShaunMKunisakiM RusselWJenningsMD.Esophageal atresia and tracheoesophageal fistula. 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