{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T05:33:26Z","timestamp":1782538406838,"version":"3.54.5"},"reference-count":52,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2021,8,20]],"date-time":"2021-08-20T00:00:00Z","timestamp":1629417600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:sec><jats:title>Objectives\/Hypothesis<\/jats:title><jats:p>Tumor\u2010infiltrating lymphocytes (TILs) predict better outcome in several types of cancers. However, the prognostic value of TILs in sinonasal mucosal melanoma (SNMM) is uncertain. Here, we investigated whether TILs can be used as a prognostic indicator for survival in SNMM.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Retrospective cohort study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patient history and histologic specimens from 27 patients with primary SNMM were retrospectively analyzed. TIL grade was determined and associations between TILs and AJCC tumor stage, overall survival, and recurrence\u2010free survival were analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Patients with TILs in the primary tumor classified as brisk or non\u2010brisk survived significantly longer than patients with SNMMs lacking lymphocyte infiltrates. Brisk TILs were associated with the lower T3 stage and increased recurrence\u2010free and 5\u2010year survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our results indicate that TIL density is a strong prognostic factor for better survival in SNMM. Prospective studies with larger case numbers are warranted to determine whether TILs should be included in future AJCC staging guidelines.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>3 <jats:italic>Laryngoscope<\/jats:italic>, 132:1334\u20131339, 2022<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.29820","type":"journal-article","created":{"date-parts":[[2021,8,20]],"date-time":"2021-08-20T09:24:27Z","timestamp":1629451467000},"page":"1334-1339","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Prognostic Value of Tumor\u2010Infiltrating Lymphocytes in Sinonasal Mucosal Melanoma"],"prefix":"10.1002","volume":"132","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7313-2088","authenticated-orcid":false,"given":"Stephan","family":"Ledderose","sequence":"first","affiliation":[{"name":"Department of Pathology Ludwig Maximilian University of Munich  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carola","family":"Ledderose","sequence":"additional","affiliation":[{"name":"Department of Surgery, Beth Israel Deaconess Medical Center Harvard Medical School  Boston Massachusetts U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josef","family":"Penkava","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Technical University of Munich  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georg J.","family":"Ledderose","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck Surgery Ludwig Maximilian University of Munich  Munich Germany"},{"name":"ENT\u2010Center Dr. L\u00fcbbers &amp; Kollegen  Weilheim Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,8,20]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2011.189"},{"key":"e_1_2_7_3_1","first-page":"27","article-title":"Human tumor\u2010infiltrating lymphocytes: a marker of host response","volume":"22","author":"Vose BM","year":"1985","journal-title":"Semin Hematol"},{"key":"e_1_2_7_4_1","first-page":"1593806","article-title":"Prognostic value of tumor\u2010infiltrating lymphocytes in melanoma: a systematic review and meta\u2010analysis","volume":"8","author":"Fu Q","year":"2019","journal-title":"Onco Targets Ther"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1159\/000505152"},{"key":"e_1_2_7_6_1","first-page":"e23","article-title":"Mucosal melanoma: new insights and therapeutic options for a unique and aggressive disease","volume":"31","author":"Lerner BA","year":"2017","journal-title":"Oncology"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11912-012-0244-x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-18-3442"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-014-3119-y"},{"key":"e_1_2_7_10_1","first-page":"185","article-title":"Sinonasal malignant melanoma","volume":"84","author":"Lund VJ","year":"2020","journal-title":"Adv Otorhinolaryngol"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijom.2019.11.001"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11912-018-0675-0"},{"key":"e_1_2_7_13_1","first-page":"739","article-title":"Primary mucosal melanomas: a comprehensive review","volume":"5","author":"Mihajlovic M","year":"2012","journal-title":"Int J Clin Exp Pathol"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2006.06.017"},{"key":"e_1_2_7_15_1","first-page":"e9483","article-title":"Mucosal melanoma: a rare entity and review of the literature","volume":"12","author":"Sohal RJ","year":"2020","journal-title":"Cureus"},{"key":"e_1_2_7_16_1","volume-title":"AJCC Cancer Staging Manual 8th edition","author":"Amin MB","year":"2016"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/81.24.1893"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pathol.2015.12.006"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrclinonc.2015.105"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc3670"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAP.0000000000000162"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2019.02.002"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellimm.2018.01.013"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrclinonc.2017.101"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.02105"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctrv.2019.101949"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000013301"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1159\/000444357"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2020.03.013"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1080\/15384047.2015.1040960"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000011387"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2009.05.034"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2006.08.9755"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.37.8539"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19960401)77:7<1303::AID-CNCR12>3.0.CO;2-5"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.12659\/MSM.905862"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1158\/2326-6066.CIR-15-0143"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2013.51.3002"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.4204"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.21037\/atm.2016.07.11"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1097\/DAD.0000000000000035"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/his.12692"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1097\/00020840-200104000-00008"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.27995"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.20910"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.21925"},{"key":"e_1_2_7_47_1","first-page":"116","article-title":"An updated review of mucosal melanoma: survival meta\u2010analysis","volume":"11","author":"Hahn HM","year":"2019","journal-title":"Mol Clin Oncol"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1097\/CMR.0000000000000306"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers12113131"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-015-1750-7"},{"key":"e_1_2_7_51_1","first-page":"47","article-title":"The side\u2010effects of head and neck tumors radiotherapy","volume":"41","author":"Skiba\u2010Tatarska M","year":"2016","journal-title":"Pol Merkur Lekarski"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjps.2010.07.006"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41379-019-0402-x"}],"container-title":["The Laryngoscope"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lary.29820","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/lary.29820","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lary.29820","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,23]],"date-time":"2023-08-23T22:27:12Z","timestamp":1692829632000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/lary.29820"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,20]]},"references-count":52,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2022,7]]}},"alternative-id":["10.1002\/lary.29820"],"URL":"https:\/\/doi.org\/10.1002\/lary.29820","archive":["Portico"],"relation":{},"ISSN":["0023-852X","1531-4995"],"issn-type":[{"value":"0023-852X","type":"print"},{"value":"1531-4995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,8,20]]},"assertion":[{"value":"2021-06-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-08-06","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-08-20","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}