{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T13:44:40Z","timestamp":1787060680232,"version":"build-2736575974"},"reference-count":30,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2021,9,8]],"date-time":"2021-09-08T00:00:00Z","timestamp":1631059200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives\/Hypothesis<\/jats:title>\n                    <jats:p>This study aimed to analyze the feasibility of transnasal humidified rapid\u2010insufflation ventilatory exchange (THRIVE) during laryngeal microsurgery (LMS) and investigated its efficiency and application according to the location of the lesion.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design<\/jats:title>\n                    <jats:p>Retrospective chart review.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Patients over 20\u2009years of age who underwent LMS without underlying cardiac, pulmonary, or cerebrovascular disease were retrospectively reviewed. Overall, 54 patients with endotracheal intubation (ETI) and 44 patients with THRIVE were included. The operation and anesthesia time, induction and emergence time, oxygen saturation (SpO\n                      <jats:sub>2<\/jats:sub>\n                      ), and transcutaneous carbon dioxide (TcCO\n                      <jats:sub>2<\/jats:sub>\n                      ) levels were analyzed and compared between the two ventilation methods according to disease subsite.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Compared with ETI, patients with THRIVE presented reduced operation time (16.3\u2009\u00b1\u20099.69\u2009min vs. 21.9\u2009\u00b1\u200912.0\u2009min), anesthesia time (33.6\u2009\u00b1\u200911.4\u2009min vs. 45.4\u2009\u00b1\u200913.9\u2009min), emergence time (6.73\u2009\u00b1\u20092.49\u2009min vs. 8.52\u2009\u00b1\u20093.17\u2009min), without significant decreases in SpO\n                      <jats:sub>2<\/jats:sub>\n                      but with increased TcCO\n                      <jats:sub>2<\/jats:sub>\n                      (10.9\u2009\u00b1\u20096.12% vs. 7.33\u2009\u00b1\u20093.86%). Comparing THRIVE to ETI for lesions at the glottis yielded similar findings, which were particularly more significant. However, lesions above the glottis presented no significant difference for any parameters between THRIVE and ETI groups. Lesions involving multiple subsites and prolonged operation time were risk factors for the intraoperative conversion of ventilation method.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>THRIVE is reliable for maintaining oxygenation during LMS and is efficient in reducing the operation and emergence times, leading to shorter anesthesia time, especially for lesions at the glottis. However, caution is required administering THRIVE, when lesion involves multiple subsites, and when operation time is prolonged.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Level of Evidence<\/jats:title>\n                    <jats:p>\n                      3\n                      <jats:italic>Laryngoscope<\/jats:italic>\n                      , 132:1061\u20131068, 2022\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/lary.29848","type":"journal-article","created":{"date-parts":[[2021,9,8]],"date-time":"2021-09-08T08:43:17Z","timestamp":1631090597000},"page":"1061-1068","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Application and Efficiency of Transnasal Humidified Rapid\u2010Insufflation Ventilatory Exchange in Laryngeal Microsurgery"],"prefix":"10.1002","volume":"132","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4487-1361","authenticated-orcid":false,"given":"Gene","family":"Huh","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology\u2010Head and Neck Surgery Seoul National University Hospital  Seoul Republic of Korea"},{"name":"Department of Otorhinolaryngology\u2010Head and Neck Surgery Seoul National University College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0945-0177","authenticated-orcid":false,"given":"Seihee","family":"Min","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Pain Medicine Chung\u2010Ang University Hospital, Chung\u2010Ang University College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7140-6863","authenticated-orcid":false,"given":"Sung\u2010Dong","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2010Head and Neck Surgery Seoul National University Hospital  Seoul Republic of Korea"},{"name":"Department of Otorhinolaryngology\u2010Head and Neck Surgery Seoul National University College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6478-8616","authenticated-orcid":false,"given":"Youn Joung","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Pain Medicine Seoul National University Hospital, Seoul National University College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9218-7666","authenticated-orcid":false,"given":"Seong Keun","family":"Kwon","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2010Head and Neck Surgery Seoul National University Hospital  Seoul Republic of Korea"},{"name":"Department of Otorhinolaryngology\u2010Head and Neck Surgery Seoul National University College of Medicine  Seoul Republic of Korea"},{"name":"Cancer Research Institute Seoul National University  Seoul Republic of Korea"},{"name":"Sensory Organ Research Institute Seoul National University Medical Research Center  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,9,8]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-198002000-00019"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00627637"},{"key":"e_1_2_7_4_1","first-page":"2","article-title":"Jet ventilation","volume":"7","author":"Evans E","year":"2007","journal-title":"BJA 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