{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T11:05:11Z","timestamp":1791889511059,"version":"4.3.4"},"reference-count":117,"publisher":"Wiley","issue":"S6","license":[{"start":{"date-parts":[[2021,9,20]],"date-time":"2021-09-20T00:00:00Z","timestamp":1632096000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives\/Hypotheses<\/jats:title>\n                    <jats:p>Children with unilateral sensory hearing loss (UHL) struggle to understand speech in noise and locate the origin of sound and have reduced quality of hearing. This clinical trial will determine the benefits of cochlear implantation in children with UHL.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design<\/jats:title>\n                    <jats:p>Prospective clinical trial.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Twenty children with at least moderate to profound sensory hearing loss and poor speech perception (word score &lt;30%) in one ear and normal hearing in the contralateral ear participated in a Food and Drug Administration\u2010approved clinical trial. Subjects were evaluated for speech perception in quiet, speech perception in noise, sound localization, and subjective benefits after implantation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      CNC word score perception in quiet significantly improved (1% to 50%,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u2009.0001) by 12 months after activation. Speech perception in noise by BKB\u2010SIN significantly improved in all three noise configurations; there was a 3.6\u2009dB advantage in head shadow (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u2009.0001), a 1.6\u2009dB advantage in summation (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.003), and a 2.5\u2009dB advantage in squelch (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.0001). Localization improved by 26\u00b0 at 9\u2009months (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u2009.0001). Speech, Spatial, and Qualities (SSQ) demonstrated significant improvements in speech (5.2 to 7.4,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.0012), qualities of hearing (5.9 to 7.5,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.0056), and spatial hearing (2.7 to 6.6,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u2009.0001). SSQ subscales associated with binaural hearing were significantly improved, as was listening effort (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.0082). Subjects demonstrated a non\u2010significant improvement in fatigue.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study demonstrates that children with UHL significantly benefit from cochlear implantation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Level of Evidence<\/jats:title>\n                    <jats:p>\n                      Level 3\n                      <jats:italic>Laryngoscope<\/jats:italic>\n                      , 132:S1\u2013S18, 2022\n                    <\/jats:p>\n                  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