{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T20:38:47Z","timestamp":1769632727944,"version":"3.49.0"},"reference-count":58,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2021,9,18]],"date-time":"2021-09-18T00:00:00Z","timestamp":1631923200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:sec><jats:title>Objectives\/Hypothesis<\/jats:title><jats:p>In otolaryngology, \u03b3\u2010aminobutyric acid (GABA) analogues have been previously analyzed for their roles in neuropathic pain, chronic cough, tinnitus, and perioperative analgesia. The primary aim of this study is to comprehensively summarize and synthesize the existing evidence for lesser known uses of gabapentin and pregabalin in otolaryngology.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>A scoping review conducted of the available English\u2010language literature was performed by two authors through April 1, 2021.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The Preferred Reporting Items for Systematic Review and Meta\u2010Analysis criteria were followed, and a quality assessment of included studies was performed using the Methodological Index for Non\u2010Randomized Studies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Ten studies met inclusion criteria. Three studies found that gabapentin may reduce gastrostomy tube usage and improve swallowing function in head and neck cancer patients undergoing radiation therapy (RT). Three studies suggested that gabapentin may help reduce opiate use when used as a primary analgesic in patients with radiation\u2010induced mucositis. One study demonstrated that pregabalin\u2010reduced trismus severity in patients with radiotherapy\u2010induced trismus. One study demonstrated gabapentin may be useful in patients with phonasthenia. Two studies demonstrated that GABA analogues may be a useful adjunct in patients with globus pharyngeus in the context of likely laryngeal sensory neuropathy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The most promising potential uses for GABA analogues identified in this review are for improving swallowing, trismus, and narcotic overuse after RT. The benefit of GABA analogues for improving nonorganic voice disorders is also promising while the benefit for globus pharyngeus when possibly related to laryngeal sensory neuropathy is inconclusive. <jats:italic>Laryngoscope<\/jats:italic>, 132:954\u2013964, 2022<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.29855","type":"journal-article","created":{"date-parts":[[2021,9,18]],"date-time":"2021-09-18T15:00:22Z","timestamp":1631977222000},"page":"954-964","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Lesser Known Uses of \u03b3\u2010Aminobutyric Acid Analogue Medications in Otolaryngology"],"prefix":"10.1002","volume":"132","author":[{"given":"Nathaniel","family":"Miller","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Walter Reed National Military Medical Center  Bethesda Maryland U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4065-483X","authenticated-orcid":false,"given":"Michael","family":"Noller","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Walter Reed National Military Medical Center  Bethesda Maryland U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9220-9543","authenticated-orcid":false,"given":"Alex","family":"Yang","sequence":"additional","affiliation":[{"name":"F. 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