{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T12:30:35Z","timestamp":1779366635716,"version":"3.53.0"},"reference-count":35,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2021,9,20]],"date-time":"2021-09-20T00:00:00Z","timestamp":1632096000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:sec><jats:title>Objectives\/Hypothesis<\/jats:title><jats:p>This study offers an update on the epidemiologic and prognostic factors and treatment\u2010specific outcomes in patients diagnosed with sinonasal diffuse large B\u2010cell lymphoma (DLBCL).<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Retrospective cohort study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>National Cancer Database was queried from 2004 to 2016 for patients with sinonasal DLBCL. Univariate Kaplan\u2010Meier and multivariate Cox\u2010regression analyses were performed to evaluate the association of suspected prognostic factors with overall survival (OS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 2,222 patients with sinonasal DLBCL were analyzed. OS was 62% at 5\u2009years and 42% at 10\u2009years. Prognostic factors associated with increased survival included African\u2010American race (HR: 0.48, 95% CI: 0.33\u20130.70), chemotherapy (HR: 0.30, CI: 0.25\u20130.35), and radiation (HR: 0.80, CI: 0.69\u20130.93). Prognostic factors associated with decreased survival included patients with Charlson\u2010Deyo scores of 1 (HR: 1.51, CI: 1.25\u20131.84), 2 (HR: 2.25, CI: 1.67\u20133.03), and 3 (HR: 2.36, CI: 1.49\u20133.74) and patients with Lugano stage III (HR: 1.69, CI: 1.09\u20132.62) and IV (HR: 1.96, CI: 1.46\u20132.64) disease. Stage\u2010based split multivariate analysis was performed and revealed chemotherapy was independently associated with increased OS in patients with stage I (HR: 0.24, CI: 0.19\u20130.30), II (HR: 0.17, CI: 0.11\u20130.28), and IV (HR: 0.41, CI: 0.26\u20130.64) disease. Radiotherapy was independently associated with increased OS in patients with stage I disease only (HR: 0.67, CI: 0.55\u20130.83), while immunotherapy was an independent prognostic factor in patients with stage IV disease only (HR: 0.60, CI: 0.37\u20130.98).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study is the largest to date to analyze the association of demographic features and treatment modalities with OS in patients with sinonasal DLBCL. It is the first to investigate the association of immunotherapy with OS in this population. A combination treatment of immunochemotherapy or radioimmunochemotherapy confers increased survival, particularly in patients with advanced disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>4<jats:italic>Laryngoscope<\/jats:italic>, 132:1515\u20131522, 2022<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.29864","type":"journal-article","created":{"date-parts":[[2021,9,20]],"date-time":"2021-09-20T12:03:52Z","timestamp":1632139432000},"page":"1515-1522","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Prognostic Indicators of Survival in Sinonasal Diffuse Large<scp>B\u2010Cell<\/scp>Lymphoma: A National Cancer Database Analysis"],"prefix":"10.1002","volume":"132","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1188-6858","authenticated-orcid":false,"given":"Hannah J.","family":"Brown","sequence":"first","affiliation":[{"name":"Rush Medical College Rush University Medical Center Chicago Illinois U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleni A.","family":"Varelas","sequence":"additional","affiliation":[{"name":"Rush Medical College Rush University Medical Center Chicago Illinois U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashwin","family":"Ganti","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology University of Minnesota Minneapolis Minnesota U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Papagiannopoulos","sequence":"additional","affiliation":[{"name":"Rush Sinus Program, Department of Otorhinolaryngology\u2014Head and Neck Surgery Rush University Medical Center Chicago Illinois U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle","family":"Mark","sequence":"additional","affiliation":[{"name":"Rush Sinus Program, Department of Otorhinolaryngology\u2014Head and Neck Surgery Rush University Medical Center Chicago Illinois U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3475-0718","authenticated-orcid":false,"given":"Edward C.","family":"Kuan","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery University of California Irvine California U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bobby A.","family":"Tajudeen","sequence":"additional","affiliation":[{"name":"Rush Sinus Program, Department of Otorhinolaryngology\u2014Head and Neck Surgery Rush University Medical Center Chicago Illinois 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