{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T20:55:08Z","timestamp":1790283308135,"version":"4.1.0"},"reference-count":44,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2021,10,4]],"date-time":"2021-10-04T00:00:00Z","timestamp":1633305600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:sec><jats:title>Objectives\/Hypothesis<\/jats:title><jats:p>To investigate the efficacy of low\u2010fat, low\u2010quick\u2010release sugar, high\u2010protein, alkaline, and plant\u2010based diet as single treatment for patients with laryngopharyngeal reflux (LPR).<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Cross\u2010over observational study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with LPR diagnosis at the hypopharyngeal\u2010esophageal multichannel intraluminal impedance\u2010pH\u2010monitoring were prospectively recruited from the reflux clinic of three University Hospitals. Patients were instructed to follow low\u2010fat, low\u2010quick\u2010release sugar, high\u2010protein, alkaline, and plant\u2010based diet for 6 to 12\u2009weeks. Pre\u2010 to post\u2010treatment symptom and finding changes were evaluated with reflux symptom score (RSS) and reflux sign assessment. Findings were compared to those of a control period where patients did not receive any treatment or diet. Diet was evaluated with refluxogenic diet score (REDS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fifty patients completed the study (19 males). Otolaryngological, digestive, and total RSS scores significantly improved from baseline to 6\u2010week post\u2010diet, while there were no significant changes during the control period. At 6\u2010week post\u2010diet, 37 (74%) patients reported significant symptom improvement or relief. Among them, symptoms continued to improve from 6 to 12\u2009weeks in 27 cases, corresponding to a diet success rate of 54%. The REDS was predictive of the baseline RSS (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.031).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Low\u2010fat, low\u2010quick\u2010release sugar, high\u2010protein, alkaline, and plant\u2010based diet is an alternative cost\u2010effective therapeutic approach for patients with LPR. Patients with higher REDS reported higher baseline symptom score.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>3 <jats:italic>Laryngoscope<\/jats:italic>, 132:1916\u20131923, 2022<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.29890","type":"journal-article","created":{"date-parts":[[2021,10,6]],"date-time":"2021-10-06T10:18:20Z","timestamp":1633515500000},"page":"1916-1923","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["Is Diet Sufficient as Laryngopharyngeal Reflux Treatment? A Cross\u2010Over Observational Study"],"prefix":"10.1002","volume":"132","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0845-0845","authenticated-orcid":false,"given":"Jerome R.","family":"Lechien","sequence":"first","affiliation":[{"name":"Department of otolaryngology Elsan Hospital  Paris France"},{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Foch Hospital, School of Medicine, University Paris Saclay  Paris France"},{"name":"Department of Otolaryngology\u2010Head and Neck Surgery CHU Saint\u2010Pierre  Brussels Belgium"},{"name":"Department of Human Anatomy and Experimental Oncology, Faculty of Medicine UMONS Research Institute for Health Sciences and Technology, University of Mons (UMons)  Mons Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lise","family":"Crevier\u2010Buchman","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Foch Hospital, School of Medicine, University Paris Saclay  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lea","family":"Distinguin","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Foch Hospital, School of Medicine, University Paris Saclay  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giannicola","family":"Iannella","sequence":"additional","affiliation":[{"name":"Department of otolaryngology Elsan Hospital  Paris France"},{"name":"Department of Head\u2010Neck Surgery, Otolaryngology, Head\u2010Neck and Oral Surgery Unit Morgagni Pierantoni Hospital  Forl\u00ec Italy"},{"name":"Department of \u201cOrgani di Senso\u201d University \u201cSapienza\u201d  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1251-0185","authenticated-orcid":false,"given":"Antonino","family":"Maniaci","sequence":"additional","affiliation":[{"name":"Department of otolaryngology Elsan Hospital  Paris France"},{"name":"Department of Medical, Surgical Sciences and Advanced Technologies G.F Ingrassia, ENT Section University of Catania  Catania Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa G.","family":"De Marrez","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Foch Hospital, School of Medicine, University Paris Saclay  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sven","family":"Saussez","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery CHU Saint\u2010Pierre  Brussels Belgium"},{"name":"Department of Human Anatomy and Experimental Oncology, Faculty of Medicine UMONS Research Institute for Health Sciences and Technology, University of Mons (UMons)  Mons Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phane","family":"Hans","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Foch Hospital, School of Medicine, University Paris Saclay  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,10,4]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599819827488"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348940311200202"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215118002256"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.29270"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.27591"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/coa.13395"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2019.05.056"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvoice.2009.10.015"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoto.2017.1454"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-021-06705-9"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11605-011-1741-1"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004836-198606001-00008"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-019-05631-1"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-019-05711-2"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.28017"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/coa.13722"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1177\/0003489419888947"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348941112000501"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348940911800913"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348940811700911"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvoice.2017.03.015"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348941212100702"},{"key":"e_1_2_6_24_1","unstructured":"Ciqual Table de composition nutritionnelle des aliments. Available at:https:\/\/ciqual.anses.fr\/. Accessed July 30 2019."},{"key":"e_1_2_6_25_1","first-page":"782","article-title":"A comparison of high and low fat meals on postprandial esophageal acid exposure","volume":"84","author":"Becker DJ","year":"1989","journal-title":"Am J Gastroenterol"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(91)90459-x"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.5555\/uri:pii:0016508589906306"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.127.5.1658"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.4103\/jfmpc.jfmpc_443_18"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gassur.2005.11.010"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(80)90922-1"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0173230"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v18.i48.7333"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.166.9.965"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2000.03347.x"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v10.i11.1647"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.2147\/TCRM.S125059"},{"key":"e_1_2_6_38_1","first-page":"377","article-title":"The effect of raw onions on acid reflux and reflux symptoms","volume":"85","author":"Allen ML","year":"1990","journal-title":"Am J Gastroenterol"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/coa.13269"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mehy.2020.110460"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2013.69"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1177\/0003489416686586"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-019-05482-w"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599813482103"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvoice.2021.03.002"}],"container-title":["The Laryngoscope"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lary.29890","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/lary.29890","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lary.29890","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,23]],"date-time":"2023-08-23T05:03:46Z","timestamp":1692767026000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/lary.29890"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10,4]]},"references-count":44,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2022,10]]}},"alternative-id":["10.1002\/lary.29890"],"URL":"https:\/\/doi.org\/10.1002\/lary.29890","archive":["Portico"],"relation":{},"ISSN":["0023-852X","1531-4995"],"issn-type":[{"value":"0023-852X","type":"print"},{"value":"1531-4995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,10,4]]},"assertion":[{"value":"2021-06-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-09-22","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-10-04","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}