{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T15:29:40Z","timestamp":1747150180775,"version":"3.40.5"},"reference-count":36,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2021,10,13]],"date-time":"2021-10-13T00:00:00Z","timestamp":1634083200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:sec><jats:title>Objectives\/Hypothesis<\/jats:title><jats:p>Preoperative anemia has been shown to be a predictor of complications in different surgeries. This has not been exclusively studied in skull base surgery. This study investigates the impact of preoperative hematocrit on complications following ventral skull base (VSB) surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Retrospective database review.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The National Surgical Quality Improvement Program was queried for all cases of VSB surgery from 2005 to 2015. Univariate and multivariate analyses were performed to investigate the impact of preoperative anemia on complications following VSB procedures.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>3,053 patients meeting inclusion criteria were identified. On univariate analysis, low hematocrit was found in 39.7% of patients and was associated with increased mean age (55.71 vs. 53.25\u2009years), male gender (63.6% vs. 36.4%), and Black race (18.5% vs. 10.9%). Preoperative anemia was also associated with increased incidences of postoperative pneumonia, blood transfusions, sepsis, medical complications, surgical complications, extended length of hospital stay (LOS), and mortality. On multivariate analysis, associations between low preoperative hematocrit and perioperative transfusions (odds ratio [OR] 2.57, 95% confidence interval [CI] 1.88\u20133.50, <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001), total surgical complications (OR 2.12, 95% CI 1.60\u20132.80, <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001), and extended LOS (OR 1.29, 95% CI 1.05\u20131.57, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.013) remained significant.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Low preoperative hematocrit is associated with increased risk of postoperative complications and extended LOS in patients undergoing VSB surgery. This study highlights the importance of careful preoperative assessment and management of anemia in these patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>3 <jats:italic>Laryngoscope<\/jats:italic>, 132:1707\u20131713, 2022<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.29893","type":"journal-article","created":{"date-parts":[[2021,10,17]],"date-time":"2021-10-17T02:57:12Z","timestamp":1634439432000},"page":"1707-1713","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Complication Risk in Ventral Skull Base Surgery Based on Preoperative Hematocrit"],"prefix":"10.1002","volume":"132","author":[{"given":"Liam S.","family":"Flanagan","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Rutgers New Jersey Medical School  Newark New Jersey U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8380-8811","authenticated-orcid":false,"given":"Chris B.","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Rutgers New Jersey Medical School  Newark New Jersey U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehdi S.","family":"Lemdani","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Rutgers New Jersey Medical School  Newark New Jersey U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aakash","family":"Shah","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Rutgers New Jersey Medical School  Newark New Jersey U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5368-1335","authenticated-orcid":false,"given":"Aksha","family":"Parray","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Rutgers New Jersey Medical School  Newark New Jersey U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7239-1467","authenticated-orcid":false,"given":"Donata","family":"Sukyte\u2010Raube","sequence":"additional","affiliation":[{"name":"Center of Ear, Nose, and Throat Diseases, Vilnius University Hospital Santaros Clinics  Vilnius Lithuania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6047-2788","authenticated-orcid":false,"given":"Christina H.","family":"Fang","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Rutgers New Jersey Medical School  Newark New Jersey U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soly","family":"Baredes","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Rutgers New Jersey Medical School  Newark New Jersey U.S.A."},{"name":"Center for Skull Base and Pituitary Surgery Neurological Institute of New Jersey, Rutgers New Jersey Medical School  Newark New Jersey U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2893-7818","authenticated-orcid":false,"given":"Jean Anderson","family":"Eloy","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Rutgers New Jersey Medical School  Newark New Jersey U.S.A."},{"name":"Center for Skull Base and Pituitary Surgery Neurological Institute of New Jersey, Rutgers New Jersey Medical School  Newark New Jersey U.S.A."},{"name":"Department of Neurological Surgery Rutgers New Jersey Medical School  Newark New Jersey U.S.A."},{"name":"Department of Ophthalmology and Visual Science Rutgers New Jersey Medical School  Newark New Jersey U.S.A."},{"name":"Department of Otolaryngology and Facial Plastic Surgery Saint Barnabas Medical Center\u2013RWJBarnabas Health  Livingston New Jersey U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,10,13]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.20186"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coms.2009.10.005"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.3109\/02688697.2012.673649"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21248"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clineuro.2018.02.032"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.22433"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2015.02.027"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.h3037"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0b013e31819878d3"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aeu098"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)61381-0"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.718353"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.9861"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0166635"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-06-508325"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1213\/01.ANE.0000184124.29397.EB"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0039-1677683"},{"key":"e_1_2_6_19_1","unstructured":"ABIM laboratory test reference ranges \u2010 January 2020.2020. Available at:https:\/\/www.abim.org\/~\/media\/ABIM%20Public\/Files\/pdf\/exam\/laboratory-reference-ranges.pdf. Accessed October 13 2020."},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.28228"},{"key":"e_1_2_6_21_1","unstructured":"User guide for the 2014 ACS NSQIP participant use data file. American College of Surgeons;2015."},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.14740\/jocmr3221w"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-05-1812"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.25788"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clineuro.2018.06.015"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2006.06047.x"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.1998.38111299056308.x"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2010.09.015"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2019.0554"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/tme.12476"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(19)30349-8"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)32555-8"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0000000000003198"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0000000000002549"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2017.6369"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjoms.2019.05.001"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.26560"}],"container-title":["The Laryngoscope"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lary.29893","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/lary.29893","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lary.29893","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T22:05:24Z","timestamp":1692741924000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/lary.29893"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10,13]]},"references-count":36,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2022,9]]}},"alternative-id":["10.1002\/lary.29893"],"URL":"https:\/\/doi.org\/10.1002\/lary.29893","archive":["Portico"],"relation":{},"ISSN":["0023-852X","1531-4995"],"issn-type":[{"type":"print","value":"0023-852X"},{"type":"electronic","value":"1531-4995"}],"subject":[],"published":{"date-parts":[[2021,10,13]]},"assertion":[{"value":"2020-12-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-09-22","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-10-13","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}