{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T09:59:55Z","timestamp":1791107995594,"version":"4.1.0"},"reference-count":82,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2021,10,15]],"date-time":"2021-10-15T00:00:00Z","timestamp":1634256000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Recent material science advancements are driving tracheal stent innovation. We sought to assess the state of the science regarding materials and preclinical\/clinical outcomes for tracheal stents in adults with benign tracheal disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A comprehensive literature search in April 2021 identified 556 articles related to tracheal stents. One\u2010hundred and twenty\u2010eight full\u2010text articles were reviewed and 58 were included in the final analysis. Datapoints examined were stent materials, clinical applications and outcomes, and preclinical findings, including emerging technologies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the 58 included studies, stent materials were metals (n\u00a0=\u00a028), polymers (n\u00a0=\u00a019), coated stents (n\u00a0=\u00a019), and drug\u2010eluting (n\u00a0=\u00a05). Metals included nitinol, steel, magnesium alloys, and elgiloy. Studies utilized 10 different polymers, the most popular included polydioxanone, poly\u2010<jats:sc>l<\/jats:sc>\u2010lactic acid, poly(<jats:sc>d<\/jats:sc>,<jats:sc>l<\/jats:sc>\u2010lactide\u2010co\u2010glycolide), and polycaprolactone. Coated stents employed a metal or polymer framework and were coated with polyurethane, silicone, polytetrafluoroethylene, or polyester, with some polymer coatings designed specifically for drug elution. Drug\u2010eluting stents utilized mitomycin C, arsenic trioxide, paclitaxel, rapamycin, and doxycycline. Of the 58 studies, 18 were human and 40 were animal studies (leporine\u00a0=\u00a021, canine\u00a0=\u00a09, swine\u00a0=\u00a04, rat\u00a0=\u00a03, ovine\/feline\/murine\u00a0=\u00a01). Noted complications included granulation tissue and\/or stenosis, stent migration, death, infection, and fragmentation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>An increasing diversity of materials and coatings are employed for tracheal stents, growing more pronounced over the past decade. Though most studies are still preclinical, awareness of tracheal stent developments is important in contextualizing novel stent concepts and clinical trials.<jats:italic>Laryngoscope<\/jats:italic>, 132:2111\u20132123, 2022<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.29904","type":"journal-article","created":{"date-parts":[[2021,10,20]],"date-time":"2021-10-20T12:53:25Z","timestamp":1634734405000},"page":"2111-2123","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["State of the Science in Tracheal Stents: A Scoping Review"],"prefix":"10.1002","volume":"132","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4934-8836","authenticated-orcid":false,"given":"Christopher M.","family":"Johnson","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Naval Medical Center\u2010San Diego San Diego California 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