{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:15:49Z","timestamp":1790727349077,"version":"4.1.0"},"reference-count":37,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2021,10,21]],"date-time":"2021-10-21T00:00:00Z","timestamp":1634774400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100007180","name":"Children's Hospital Colorado","doi-asserted-by":"publisher","award":["COEPS grant"],"award-info":[{"award-number":["COEPS grant"]}],"id":[{"id":"10.13039\/100007180","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010174","name":"University of Colorado","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010174","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:sec><jats:title>Objectives\/Hypothesis<\/jats:title><jats:p>Children who do not require oxygen beyond 3\u2009hours after surgery and pass a sleep room air challenge (SRAC) are safe for discharge regardless of polysomnogram (PSG) results or comorbidities.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Cross\u2010sectional prospective study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>All children observed overnight undergoing an adenotonsillectomy for obstructive sleep\u2010disordered breathing were prospectively recruited. Demographic, clinical, and PSG characteristics were stratified by whether the patient had required oxygen beyond 3\u2009hours postoperatively (prolonged oxygen requirement [POR]) and compared using <jats:italic>t<\/jats:italic> test, chi\u2010squared test, or Fisher's exact test depending on distribution. Optimal cut points for predicting POR postsurgery were calculated using receiver operating characteristic curves. The primary analysis was performed on the full cohort via logistic regression using POR as the outcome. Significant characteristics were analyzed in a logistic regression model, with significance set at <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.05.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 484 participants met the inclusion criteria. The mean age was 5.65 (standard deviation\u00a0=\u00a04.02) years. Overall, 365 (75%) did not have a POR or any other adverse respiratory event. In multivariable logistic regression, risk factors for POR were an asthma diagnosis (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001) and an awake SpO<jats:sub>2<\/jats:sub>\u2009&lt;96% (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.005). The probability of a POR for those without asthma and a SpO<jats:sub>2<\/jats:sub>\u2009\u2265\u200996% was 18% (95% confidence interval: 14\u201322). Age, obesity, and obstructive apnea\/hypopnea index were not associated with POR.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In conclusion, all children in our study who are off oxygen within 3\u2009hours of surgery and passed a SRAC were safe for discharge from a respiratory standpoint regardless of age, obesity status, asthma diagnosis, and obstructive apnea\/hypopnea index. Additional investigations are necessary to confirm our findings.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>3 <jats:italic>Laryngoscope<\/jats:italic>, 132:1675\u20131681, 2022<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.29909","type":"journal-article","created":{"date-parts":[[2021,10,21]],"date-time":"2021-10-21T17:59:14Z","timestamp":1634839154000},"page":"1675-1681","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Tonsillectomy for Obstructive Sleep\u2010Disordered Breathing: Should They Stay, or Could They Go?"],"prefix":"10.1002","volume":"132","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3982-0650","authenticated-orcid":false,"given":"Norman R.","family":"Friedman","sequence":"first","affiliation":[{"name":"Department of Otolaryngology University of Colorado School of Medicine  Aurora Colorado U.S.A."},{"name":"Division of Pediatric Otolaryngology Children's Hospital Colorado  Aurora Colorado U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maxene","family":"Meier","sequence":"additional","affiliation":[{"name":"The Center for Research in Outcomes for Children's Surgery University of Colorado School of Medicine  Aurora Colorado U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaitlyn","family":"Tholen","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology University of Colorado School of Medicine  Aurora Colorado U.S.A."},{"name":"Division of Pediatric Otolaryngology Children's Hospital Colorado  Aurora Colorado U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renee","family":"Crowder","sequence":"additional","affiliation":[{"name":"University of Colorado School of Medicine  Aurora Colorado U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Regina","family":"Hoefner\u2010Notz","sequence":"additional","affiliation":[{"name":"Perioperative Services Children's Hospital Colorado  Aurora Colorado U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thanh","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Division of Pediatric Anesthesia Children's Hospital Colorado  Aurora Colorado U.S.A."},{"name":"Department of Anesthesiology, School of Medicine University of Colorado  Aurora Colorado U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Derieg","sequence":"additional","affiliation":[{"name":"Ambulatory Services Children's Hospital Colorado  Aurora Colorado U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristen","family":"Campbell","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of Colorado School of Medicine  Aurora Colorado U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"McLeod","sequence":"additional","affiliation":[{"name":"Pediatric Center of Excellence, Global Product Development Pfizer, Inc.  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