{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:49:45Z","timestamp":1786978185110,"version":"build-2736575974"},"reference-count":36,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,10,28]],"date-time":"2021-10-28T00:00:00Z","timestamp":1635379200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>We performed a systematic review and meta\u2010analysis of randomized controlled trials (RCTs) that scrutinized the oncological benefits and postsurgical complications of total thyroidectomy (TT) plus prophylactic central neck dissection (pCND) versus TT alone among clinically node\u2010negative (cN0) papillary thyroid cancer (PTC) patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We screened five databases from inception to September 4, 2021 and evaluated the risk of bias of the eligible studies. We pooled dichotomous outcomes using the risk ratio (RR) with 95% confidence interval (CI).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Overall, we included 5 RCTs with low risk of bias comprising 795 patients (TT plus pCND\u00a0=\u00a0410 and TT alone\u00a0=\u00a0385). With regard to efficacy endpoint, the rate of structural loco\u2010regional recurrence did not significantly differ between both groups (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u20094 RCTs, RR\u00a0=\u00a00.49, 95% CI [0.19, 1.27],\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u2009.14). With regard to safety endpoints, the rates of hypoparathyroidism (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u20095 RCTs, RR\u00a0=\u00a01.48, 95% CI [0.73, 2.97],\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u2009.27), recurrent laryngeal nerve injury (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u20095 RCTs, RR\u00a0=\u00a01.34, 95% CI [0.59, 3.03],\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u2009.48), and bleeding (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u20093 RCTs, RR\u00a0=\u00a01.75, 95% CI [0.42, 7.26],\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u2009.44) did not significantly differ between both groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>For cN0 PTC patients, there was no significant difference between TT plus pCND and TT alone with regard to the rate of structural loco\u2010regional recurrence or frequency of postsurgical complications. Adaptation of pCND in cN0 PTC patients should be contemplated by taking into consideration the clinical oncological benefits and rate of postsurgical adverse events.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Level of Evidence<\/jats:title>\n                    <jats:p>\n                      1\n                      <jats:italic>Laryngoscope<\/jats:italic>\n                      , 132:1320\u20131328, 2022\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/lary.29912","type":"journal-article","created":{"date-parts":[[2021,10,28]],"date-time":"2021-10-28T07:37:15Z","timestamp":1635406635000},"page":"1320-1328","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["Prophylactic Central Neck Dissection for Clinically Node\u2010Negative Papillary Thyroid Carcinoma"],"prefix":"10.1002","volume":"132","author":[{"given":"Khaled M.","family":"Alsubaie","sequence":"first","affiliation":[{"name":"Department of Surgery Alhada Armed Forces Hospital  Taif Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3127-9644","authenticated-orcid":false,"given":"Hemail M.","family":"Alsubaie","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery King Abdullah Medical City  Makkah Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faisal R.","family":"Alzahrani","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery College of Medicine, King Saud University  Riyadh Saudi Arabia"},{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Western University Schulich School of Medicine and Dentistry  London Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad A.","family":"Alessa","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery King Abdullah Medical City  Makkah Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1695-0898","authenticated-orcid":false,"given":"Sherif K.","family":"Abdulmonem","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery King Abdullah Medical City  Makkah Saudi Arabia"},{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, Faculty of Medicine Ain Shams University  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mazin A.","family":"Merdad","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery King Abdulaziz University  Jeddah Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Talal","family":"Al\u2010Khatib","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery King Abdulaziz University  Jeddah Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0707-1851","authenticated-orcid":false,"given":"Hani Z.","family":"Marzouki","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery King Abdulaziz University  Jeddah Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed A.","family":"Algarni","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery King Saud Bin Abdulaziz University for Health Sciences, National Guard Hospital  Jeddah Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ameen Z.","family":"Alherabi","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery King Faisal Specialist Hospital and Research Center  Jeddah Saudi Arabia"},{"name":"Department of Otolaryngology\u2013Head and Neck Surgery College of Medicine, Umm Al\u2010Qura University  Makkah Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,10,28]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1210\/er.2019-00085"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijso.2020.05.002"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000004345"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2009.0159"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2009.0110"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-019-05702-3"},{"key":"e_1_2_6_8_1","first-page":"51","article-title":"Does central lymph node dissection in patients with papillary thyroid carcinoma increase morbidity rates? 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