{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T15:04:04Z","timestamp":1788188644070,"version":"build-2803163510"},"reference-count":29,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2021,11,24]],"date-time":"2021-11-24T00:00:00Z","timestamp":1637712000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:sec><jats:title>Objectives\/Hypothesis<\/jats:title><jats:p>Evaluation of the clinical outcomes after 6 months of treatment with a novel adjustable implant, the APrevent\u00ae Vocal\u2010Implant\u2010System (VOIS), in conjunction with medialization thyroplasty (MT) in patients with unilateral vocal fold paralysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Prospective case series study at single tertiary referral center.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Preoperative and 1\u2009week, 7\u2009weeks, and 6\u2009months postoperative glottal efficiency (maximum phonation time [MPT]), voice quality (including GRBAS\u2010scores and acoustic parameters) and self\u2010perceived voice\u2010related handicap (voice handicap index [VHI\u201030]) were measured and analyzed, whereas type of vocal fold closure was evaluated and determined by flexible videolaryngoscopy based on S\u00f6dersten and Lindestad classification (Wilcoxon signed\u2010rank test).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirteen patients underwent MT with VOIS under local anesthesia. Six months after surgery, the VHI\u201030 and MPT had improved from a preoperative mean of 75.0\u2009\u00b1\u200922.9 and 2.7\u00a0\u00b1\u20092.1\u00a0s to a postoperative mean of 20.6\u00a0\u00b1\u200919.7 and 6.3\u00a0\u00b1\u20094.0\u2009s, respectively. The mean GRBAS score improved from preoperative scores of G<jats:sub>preop<\/jats:sub>\u00a0=\u20092.7, R<jats:sub>preop<\/jats:sub>\u00a0=\u20092.6, B<jats:sub>preop<\/jats:sub>\u00a0=\u20092.6, A<jats:sub>preop<\/jats:sub>\u00a0=\u20092.2, and S<jats:sub>preop<\/jats:sub>\u00a0=\u20092.0 to G<jats:sub>postop<\/jats:sub>\u00a0=\u20090.3, R<jats:sub>postop<\/jats:sub>\u00a0=\u20090.3, B<jats:sub>postop<\/jats:sub>\u00a0=\u20090.2, A<jats:sub>postop<\/jats:sub>\u00a0=\u20090.2, and S<jats:sub>postop<\/jats:sub>\u00a0=\u20090.3 at 6\u2009months postoperatively. Improved glottal closure was achieved in all patients (n\u00a0=\u00a013). Five patients received postoperative adjustment for the optimization of voice quality and glottal closure. No intra\u2010 or postoperative complications were observed. Significant improvements in acoustic parameters, including percentage jitter, percentage shimmer, and signal\u2010to\u2010noise ratio, were also observed after MT. All results were statistically significant (<jats:italic>P<\/jats:italic>\u00a0&lt;\u2009.05, Cohen's d\u2009&gt;\u2009.8).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>APrevent\u00ae VOIS\u2010Implantation is a safe procedure with good voice outcomes. Postoperative adjustments can be performed smoothly to optimize voice quality and glottal closure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>3 <jats:italic>Laryngoscope<\/jats:italic>, 132:1622\u20131629, 2022<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.29958","type":"journal-article","created":{"date-parts":[[2021,11,25]],"date-time":"2021-11-25T08:00:04Z","timestamp":1637827204000},"page":"1622-1629","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Preliminary Clinical Outcomes of <scp>VOIS<\/scp>\u2010Implant in Patients With Unilateral Vocal Fold Paralysis"],"prefix":"10.1002","volume":"132","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1523-0098","authenticated-orcid":false,"given":"Li\u2010Chun","family":"Hsieh","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Mackay Memorial Hospital  Taipei Taiwan"},{"name":"Department of Audiology and Speech Language Pathology Mackay Medical College  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8176-128X","authenticated-orcid":false,"given":"Chin\u2010Kuo","family":"Chen","sequence":"additional","affiliation":[{"name":"Communication Enhancement Center and Department of Otolaryngology\u2010Head and Neck Surgery Chang Gung Memorial Hospital  Taoyuan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chin\u2010Wen","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Mackay Memorial Hospital  Taipei Taiwan"},{"name":"Department of Audiology and Speech Language Pathology Mackay Medical College  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi\u2010Shing","family":"Leu","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Mackay Memorial Hospital  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2038-0085","authenticated-orcid":false,"given":"Guan\u2010Min","family":"Ho","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Mackay Memorial Hospital  Taipei Taiwan"},{"name":"Yomin ENT and Pediatric Clinic APrevent Medical  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,11,24]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.28401"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.25739"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016487409126379"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215116010033"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2273.2000.00395.x"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1978.00790100009002"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.20171"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200108000-00003"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40136-014-0044-y"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.21455"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1067\/S0892-1997(03)00080-8"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-199811000-00020"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.21004"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.21431"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-019-05756-3"},{"key":"e_1_2_6_17_1","unstructured":"HoGM CM TzouCHJ MengS ReissigL WeningerWJ HessMM.Development of a surgical procedure for UVFP patients using an adjustable implant. 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