{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T22:47:22Z","timestamp":1789426042352,"version":"build-2803163510"},"reference-count":64,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2021,12,11]],"date-time":"2021-12-11T00:00:00Z","timestamp":1639180800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>Lipoinjection is one of the available treatments for unilateral vocal fold paralysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate lipoinjection predictability, and analyze the differences in safety and efficacy of the different techniques.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Systematic review and meta\u2010analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and Results<\/jats:title><jats:p>A systematic review on Medline, Cochrane, and Scopus databases included 49 articles analyzing the data of 1,166 patients, concerning technical details and voice parameters changes. Lipoinjection used a mean volume of 1.3\u00a0mL, 95% confidence interval (CI) (0.92, 1.69)\u2014average overcorrection of 30%. Meta\u2010analysis of pre\u2010 and postoperative voice parameters' means showed a significant improvement at 6\u2009months of mean phonation time (preoperative: 5.12, 95% CI [4.48, 5.76]\u20146\u2009months: 10.46, 95% CI [9.18, 11.75]), Jitter (preoperative: 2.71, 95% CI [2.08, 3.33])\u20146\u2009months: 1.37, 95% CI [1.05, 1.70]), Shimmer (preoperative: 4.55, 95% CI [3.04, 6.07]\u20146\u2009months: 2.57, 95% CI [1.69, 3.45]), grade (preoperative: 2.15, 95% CI [1.73, 2.57]\u20146\u2009months: 0.12, 95% CI [0.97, 1.43]), breathiness (preoperative: 2.012, 95% CI [1.48, 2.55]\u20146\u2009months: 0.99, 95% CI [0.58, 1.40]), and asthenia (preoperative: 1.90, 95% CI [1.33, 2.47]\u20146\u2009months: 0.75, 95% CI [0.17, 1.33]) of GRBAS (Grade, Roughness, Breathiness, Asthenia and Strain), and Voice Handicap Index\u201030 (preoperative: 72.06, 95% CI [54.35, 89.76]\u20146\u2009months: 26.24, 95% CI [19.58, 32.90]). Subgroup analysis by harvesting technique concluded in no statistically significant difference between them. Few complications were reported. Reintervention was only required for 86 patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Lipoinjection seems a safe therapeutic option for unilateral vocal fold paralysis, with available data showing an efficacy lasting 6\u2009months to 1\u2009year. <jats:italic>Laryngoscope<\/jats:italic>, 132:1630\u20131640, 2022<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.29965","type":"journal-article","created":{"date-parts":[[2021,12,11]],"date-time":"2021-12-11T11:58:10Z","timestamp":1639223890000},"page":"1630-1640","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Lipoinjection for Unilateral Vocal Fold Paralysis Treatment: A Systematic Review and Meta\u2010Analysis"],"prefix":"10.1002","volume":"132","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1388-3848","authenticated-orcid":false,"given":"Ralph","family":"Haddad","sequence":"first","affiliation":[{"name":"Department of 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