{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T10:56:31Z","timestamp":1782125791630,"version":"3.54.5"},"reference-count":33,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2021,12,6]],"date-time":"2021-12-06T00:00:00Z","timestamp":1638748800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:sec><jats:title>Objectives\/Hypothesis<\/jats:title><jats:p>Postoperative complications may depend on the systemic inflammatory response. We evaluated the predictive potential of the combination of platelet count and neutrophil\u2010to\u2010lymphocyte ratio (COP\u2010NLR) for the incidence of pharyngocutaneous fistula (PCF) in patients who have undergone total laryngectomy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Retrospective cohort study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients who underwent total laryngectomy between 2000 and 2020 were recruited from four hospitals. The correlations between the incidence of PCF and several risk factors, including the COP\u2010NLR, were examined. Patients with both elevated platelet count and elevated neutrophil\u2010to\u2010lymphocyte ratio (NLR) were categorized as COP\u2010NLR 2, and patients with either one or no abnormal values of both parameters were assigned as COP\u2010NLR 1 and COP\u2010NLR 0, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 235 patients were identified. The overall incidence of PCF was 12.3%. The cut\u2010off value for NLR before surgery was set at 3.95 (sensitivity\u00a0=\u00a058.6%, specificity\u00a0=\u00a069.4%, area under the curve [AUC]\u00a0=\u00a00.635), and the platelet count was set at 320\u2009\u00d7\u200910<jats:sup>9<\/jats:sup>\/L (sensitivity\u00a0=\u00a027.6%, specificity\u00a0=\u00a087.9%, AUC\u00a0=\u00a00.571). Multivariate analysis revealed that COP\u2010NLR was an independent risk factor for PCF (COP\u2010NLR 1 vs. COP\u2010NLR 0: odds ratio [OR], 4.17; 95% confidence interval [CI], 1.64 to 10.59; and COP\u2010NLR 2 vs. COP\u2010NLR 0: OR, 5.33; 95% CI, 1.38 to 20.56).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>COP\u2010NLR is a novel predictive factor for the development of PCF in patients undergoing total laryngectomy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>4 <jats:italic>Laryngoscope<\/jats:italic>, 132:1582\u20131587, 2022<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.29970","type":"journal-article","created":{"date-parts":[[2021,12,6]],"date-time":"2021-12-06T10:18:15Z","timestamp":1638785895000},"page":"1582-1587","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Inflammation\u2010Based Score (Combination of Platelet Count and Neutrophil\u2010to\u2010Lymphocyte Ratio) Predicts Pharyngocutaneous Fistula After Total Laryngectomy"],"prefix":"10.1002","volume":"132","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1437-7506","authenticated-orcid":false,"given":"Shin","family":"Matsumoto","sequence":"first","affiliation":[{"name":"Department of Otolaryngology, Head and Neck Surgery, Faculty of Medicine University of Tsukuba  Tsukuba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9285-7877","authenticated-orcid":false,"given":"Masahiro","family":"Nakayama","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Head and Neck Surgery, Faculty of Medicine University of Tsukuba  Tsukuba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiko","family":"Gosho","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Faculty of Medicine University of Tsukuba  Tsukuba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bungo","family":"Nishimura","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Ibaraki Prefectural Central Hospital, Ibaraki Cancer Center  Kasama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuniaki","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Ibaraki Prefectural Central Hospital, Ibaraki Cancer Center  Kasama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomonori","family":"Yoshimura","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology National Hospital Organization Mito Medical Center  Ibarakimachi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masamitsu","family":"Senarita","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology National Hospital Organization Mito Medical Center  Ibarakimachi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirotatsu","family":"Ohara","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Tsukuba University Hospital Mito Medical Center, Mito Kyodo General Hospital  Mito Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiromitsu","family":"Akizuki","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Tsukuba University Hospital Mito Medical Center, Mito Kyodo General Hospital  Mito Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2692-7766","authenticated-orcid":false,"given":"Tetsuro","family":"Wada","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Head and Neck Surgery, Faculty of Medicine University of Tsukuba  Tsukuba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keiji","family":"Tabuchi","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Head and Neck Surgery, Faculty of Medicine University of Tsukuba  Tsukuba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,12,6]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1067\/mhn.2000.110617"},{"key":"e_1_2_6_3_1","first-page":"803","article-title":"Multicenter prospective crossover study on new prosthetic opportunities in post\u2010laryngectomy voice rehabilitation","volume":"31","author":"Serra A","year":"2017","journal-title":"J Biol Regul Homeost Agents"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.14639\/0392-100X-626"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.23804"},{"key":"e_1_2_6_6_1","first-page":"1001","article-title":"Prognostic nutritional index in 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