{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T20:47:58Z","timestamp":1792097278000,"version":"4.4.0"},"reference-count":31,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2021,12,6]],"date-time":"2021-12-06T00:00:00Z","timestamp":1638748800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100009331","name":"Beijing Municipal Administration of Hospitals Clinical Medicine Development of Special Funding Support","doi-asserted-by":"publisher","award":["XMLX201816"],"award-info":[{"award-number":["XMLX201816"]}],"id":[{"id":"10.13039\/501100009331","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81870698"],"award-info":[{"award-number":["81870698"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82101190"],"award-info":[{"award-number":["82101190"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:sec><jats:title>Objectives\/Hypothesis<\/jats:title><jats:p>Air pollution has emerged as an important environmental risk factor for chronic rhinosinusitis (CRS) progression. This study assessed exposure to five types of air pollution (PM<jats:sub>2.5\/10<\/jats:sub>, SO<jats:sub>2<\/jats:sub>, NO<jats:sub>2<\/jats:sub>, CO, O<jats:sub>3<\/jats:sub>) and explored their effects on CRS with nasal polyps (CRSwNP) severity and endotype.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Retrospective cohort study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Air pollution data from monitoring sites in Beijing were obtained to assess individual air pollution exposure. Outcomes of CRSwNP (n\u00a0=\u00a0282) including Lund\u2010Mackay (L\u2010M) score, Lund\u2010Kennedy (L\u2010K) score, visual analogue scale (VAS) score and nasal patency\/airflow resistance and so on were measured to analyze correlations with air pollution and compare groups with different exposure types. Multivariable\u2010adjusted binary logistic regression was used to determine potential air pollution risk factors of the endotype of eosinophilic CRSwNP (ECRSwNP).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Short\u2010term exposures to PM<jats:sub>2.5\/10<\/jats:sub>, SO<jats:sub>2<\/jats:sub>, CO, NO<jats:sub>2<\/jats:sub>, and O<jats:sub>3<\/jats:sub> were weak but significantly associated with increased L\u2010M scores. Short\u2010term exposures to PM<jats:sub>10<\/jats:sub>, CO, and NO<jats:sub>2<\/jats:sub> were correlated with increased VAS headache\/facial pain scores. The L\u2010M scores of the group of the highest PM<jats:sub>2.5<\/jats:sub> (\u2265150\u2009\u03bcg\/m<jats:sup>3<\/jats:sup>) exposure were significantly higher than those of control group. For each increased unit of the average concentration of PM<jats:sub>2.5<\/jats:sub>, there was a 1.047\u2010fold (95% confidence interval, 1.005\u20131.091) increased risk of the endotype of ECRSwNP.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Air pollution exposure exacerbated CRSwNP severity and PM<jats:sub>2.5<\/jats:sub> could be a risk factor for endotype of ECRSwNP, suggesting the role of air pollution in CRSwNP pathogenesis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>4 <jats:italic>Laryngoscope<\/jats:italic>, 132:2103\u20132110, 2022<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.29974","type":"journal-article","created":{"date-parts":[[2021,12,6]],"date-time":"2021-12-06T10:18:59Z","timestamp":1638785939000},"page":"2103-2110","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Air Pollution Exposure Affects Severity and Cellular Endotype of Chronic Rhinosinusitis With Nasal Polyps"],"prefix":"10.1002","volume":"132","author":[{"given":"Xiaozhe","family":"Yang","sequence":"first","affiliation":[{"name":"Research Unit of Diagnosis and Treatment of Chronic Nasal Diseases Chinese Academy of Medical Sciences  Beijing China"},{"name":"Beijing Key Laboratory of Nasal Diseases Beijing Institute of Otolaryngology  Beijing China"},{"name":"Department of Otolaryngology Head and Neck Surgery, Beijing Tongren Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shen","family":"Shen","sequence":"additional","affiliation":[{"name":"Research Unit of Diagnosis and Treatment of Chronic Nasal Diseases Chinese Academy of Medical Sciences  Beijing China"},{"name":"Beijing Key Laboratory of Nasal Diseases Beijing Institute of Otolaryngology  Beijing China"},{"name":"Department of Otolaryngology Head and Neck Surgery, Beijing Tongren Hospital Capital Medical University  Beijing 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