{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T06:02:16Z","timestamp":1791525736836,"version":"4.3.4"},"reference-count":42,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2021,12,20]],"date-time":"2021-12-20T00:00:00Z","timestamp":1639958400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:sec><jats:title>Objectives\/Hypothesis<\/jats:title><jats:p>Modulation of the pharyngeal swallow to bolus volume and viscosity is important for safe swallowing and is commonly studied using high\u2010resolution pharyngeal manometry (HRPM). Use of unidirectional pressure sensor technology may, however, introduce variability in swallow measures and a fixed bolus administration protocol may induce time and order effects. We aimed to overcome these limitations and to investigate the effect of time by repeating randomized measurements using circumferential pressure sensor technology.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Sub\u2010set analysis of data from the placebo arm of a randomized, repeated measures trial.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>HRPM with impedance was recorded using a solid\u2010state catheter with 36 circumferential pressure sensors and 18 impedance segments straddling from hypopharynx to stomach. Testing included triplicates of 5, 10, and 20\u2009ml thin liquid and 10\u2009ml thick liquid boluses, the order of the thin liquid boluses was randomized. The swallow challenges were repeated approximately 10\u00a0minutes after finishing the baseline measurement.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We included 19 healthy adults (10\/9 male\/female; age 24.5\u00a0\u00b1\u20094.1\u00a0year). Intrabolus pressure, all upper esophageal sphincter (UES) opening and relaxation metrics, and flow timing metrics increased with larger volumes. A thicker viscosity decreased UES relaxation time, UES basal pressure, and flow timing metrics, whereas UES opening extent increased. Pre\u2010swallow UES basal pressure and post\u2010swallow UES contractile integral decreased over time.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Using circumferential pressure sensor technology, the effects of volume and viscosity were largely consistent with previous reports. UES contractile pressures reduced over time. The growing body of literature offers a benchmark for recognizing aberrant pharyngo\u2010esophageal motor responses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>3 <jats:italic>Laryngoscope<\/jats:italic>, 132:1817\u20131824, 2022<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.29987","type":"journal-article","created":{"date-parts":[[2021,12,20]],"date-time":"2021-12-20T13:47:18Z","timestamp":1640008038000},"page":"1817-1824","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Pharyngo\u2010Esophageal Modulatory Swallow Responses to Bolus Volume and Viscosity Across Time"],"prefix":"10.1002","volume":"132","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2240-4271","authenticated-orcid":false,"given":"Joeke L.","family":"Nollet","sequence":"first","affiliation":[{"name":"Department of Intensive Care Medicine, Radboud University Medical Center Radboud Institute for Health Sciences  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