{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T23:36:57Z","timestamp":1778542617314,"version":"3.51.4"},"reference-count":22,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2021,12,16]],"date-time":"2021-12-16T00:00:00Z","timestamp":1639612800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Depth of invasion (DOI) has been incorporated in the new AJCC 8th classification. However, even with this new AJCC classification stage III oral tongue squamous cell carcinoma (OTSCC) remains a heterogenous group. The study aims at finding a discreet group within stage III using DOI as a cut\u2010off of 10\u2009mm.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The institutional database was reviewed from 2012 to 2018 for postoperative stage III OTSCC patients who subsequently received postoperative radiotherapy. Ninety\u2010six patients matched the inclusion criteria. Two groups were created using a DOI cut\u2010off of 10\u2009mm (superficial and deep groups). The groups were analyzed for overall survival (OS) and relapse\u2010free survival (RFS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The baseline and treatment characteristics were comparable between the groups except for the higher number of extensive surgeries, endophytic configuration, pT3 and, DOI in the deep group. For a median follow\u2010up of 40.5 (range: 4\u2013139) months, the median OS and RFS for the superficial group were not reached. The median OS and RFS for the deep group were 101 (range: 73.7\u2013128.3) and 60 (range: 46.6\u201373.4) months, respectively. The difference was statistically significant for median RFS (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.008) and trended toward significance for median OS (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.066) for the superficial group. Multivariate Cox regression analysis showed DOI cut\u2010off as a significant predictor for RFS but not for OS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>DOI significantly predicts poor RFS. However, showed a trend toward poor OS. This study hints toward a possibility of sub\u2010dividing stage III OTSCC based on DOI cut\u2010off.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>3 (Retrospective cohort study) <jats:italic>Laryngoscope<\/jats:italic>, 132:1594\u20131599, 2022<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.29990","type":"journal-article","created":{"date-parts":[[2021,12,17]],"date-time":"2021-12-17T07:36:15Z","timestamp":1639726575000},"page":"1594-1599","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Depth of Invasion as an Independent Predictor of Survival in Patients of Stage <scp>III<\/scp> Squamous Cell Carcinoma of the Oral Tongue"],"prefix":"10.1002","volume":"132","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2319-0391","authenticated-orcid":false,"given":"Sarthak","family":"Tandon","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology Rajiv Gandhi Cancer Institute and Research Centre  New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Parveen","family":"Ahlawat","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Rajiv Gandhi Cancer Institute and Research Centre  New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sunil","family":"Pasricha","sequence":"additional","affiliation":[{"name":"Department of Pathology Rajiv Gandhi Cancer Institute and Research Centre  New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandeep","family":"Purohit","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Rajiv Gandhi Cancer Institute and Research Centre  New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David K.","family":"Simson","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Rajiv Gandhi Cancer Institute and Research Centre  New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kiran","family":"Dobriyal","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Rajiv Gandhi Cancer Institute and Research Centre  New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Preetha","family":"Umesh","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Rajiv Gandhi Cancer Institute and Research Centre  New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manindra","family":"Mishra","sequence":"additional","affiliation":[{"name":"Division of Medical Physicis, Department of Radiation Oncology Rajiv Gandhi Cancer Institute and Research Centre  New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lalit","family":"Kumar","sequence":"additional","affiliation":[{"name":"Division of Medical Physicis, Department of Radiation Oncology Rajiv Gandhi Cancer Institute and Research Centre  New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmad M.","family":"Karimi","sequence":"additional","affiliation":[{"name":"Department of Oncology University Hospital of Derby and Burton  Derby England United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jwala","family":"M","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Rajiv Gandhi Cancer Institute and Research Centre  New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Munish","family":"Gairola","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Rajiv Gandhi Cancer Institute and Research Centre  New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,12,16]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-40618-3"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoto.2014.1548"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21551"},{"key":"e_1_2_6_5_1","unstructured":"GLOBOCAN 2020: estimated cancer incidence mortality and prevalence worldwide in 2020. [homepage on the internet];2020. Available at:https:\/\/gco.iarc.fr\/today\/data\/factsheets\/populations\/356-india-fact-sheets.pdf. Accessed May 17 2021."},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2021.105195"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.18203\/issn.2454-5929.ijohns20200149"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-0825.2010.01740.x"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2017.09.007"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oooo.2019.08.002"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000843"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.3857\/roj.2018.00577"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2012.09.026"},{"key":"e_1_2_6_14_1","first-page":"2559","article-title":"A prospective study of prognostic factors for recurrence in early oral tongue cancer","volume":"7","author":"Sharma P","year":"2013","journal-title":"J Clin Diagn Res"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.25506"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijom.2009.01.004"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijom.2018.07.009"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.25785"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.6696\/IJHNS.2017.0104.05"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-011-1616-4"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.23206"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(97)00817-1"},{"key":"e_1_2_6_23_1","first-page":"39","article-title":"Radiation Therapy Oncology Group (RTOG) studies in head and neck cancer","volume":"15","author":"Marcial VA","year":"1988","journal-title":"Semin Oncol"}],"container-title":["The Laryngoscope"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lary.29990","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/lary.29990","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lary.29990","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,23]],"date-time":"2023-08-23T21:27:08Z","timestamp":1692826028000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/lary.29990"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12,16]]},"references-count":22,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2022,8]]}},"alternative-id":["10.1002\/lary.29990"],"URL":"https:\/\/doi.org\/10.1002\/lary.29990","archive":["Portico"],"relation":{},"ISSN":["0023-852X","1531-4995"],"issn-type":[{"value":"0023-852X","type":"print"},{"value":"1531-4995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,12,16]]},"assertion":[{"value":"2021-08-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-11-29","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-12-16","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}