{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T18:48:07Z","timestamp":1760986087643,"version":"3.40.5"},"reference-count":28,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2022,1,7]],"date-time":"2022-01-07T00:00:00Z","timestamp":1641513600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:sec><jats:title>Objectives\/Hypothesis<\/jats:title><jats:p>Non\u2010squamous cell carcinoma (SCC) malignancies are rare, but well described laryngeal pathologies. However, the epidemiology and clinical behavior of these tumors is not well studied.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Retrospective cohort study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients diagnosed with non\u2010squamous cell larynx cancer from 2004 to 2017 in the National Cancer Database were selected. Demographic, clinicopathologic factors, treatments, and survival were analyzed. Univariable and multivariable cox regression were performed. Survival was compared with a propensity score\u2010matched (PSM) population of laryngeal SCC patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 136,235 cases of larynx cancer were identified. After excluding SCC variants, 2,172 (1.6%) patients met inclusion criteria. The most common histology was chondrosarcoma (374, 17.2%), followed by small cell (345, 15.9%), and spindle cell carcinoma (268, 12.3%). The most common treatment was surgery (683, 31.4%) followed by chemoradiation (409, 18.8%) and surgery and adjuvant radiation (288, 13.3%). Overall, 3\u2010 and 5\u2010year survival was 67.9% and 59.4%, respectively. In multivariate analysis controlling for age, stage, comorbidity, histology, and treatment modality; chondrosarcoma had the best survival (hazard ratio [HR] 0.11, confidence interval [CI] 0.07\u20130.19, <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001). In a PSM population, matched for age, stage, comorbidity, and treatments; non\u2010SCC patients had significantly lower survival (51.5% vs. 59.9%, <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>A diverse range of non\u2010squamous cell malignancies occur in the larynx. In general, these tumors have poor survival, with few exceptions such as chondrosarcoma. While the majority of these histologies undergo surgical\u2010based treatments in other sites, only 53% of patients underwent surgical\u2010based treatment in the larynx. These data could guide clinicians in determining the outcome of treatment in these patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>4 <jats:italic>Laryngoscope<\/jats:italic>, 132:1771\u20131777, 2022<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.30007","type":"journal-article","created":{"date-parts":[[2022,1,7]],"date-time":"2022-01-07T15:43:59Z","timestamp":1641570239000},"page":"1771-1777","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["<scp>Non\u2010Squamous<\/scp> Cell Malignancies of the Larynx"],"prefix":"10.1002","volume":"132","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3187-5008","authenticated-orcid":false,"given":"Janine M.","family":"Rotsides","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery New York University Langone Health  New York New York U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9300-4390","authenticated-orcid":false,"given":"Evan","family":"Patel","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery New York University Langone Health  New York New York U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jamie R.","family":"Oliver","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery New York University Langone Health  New York New York U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7627-170X","authenticated-orcid":false,"given":"Lindsey E.","family":"Moses","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery New York University Langone Health  New York New York U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adam S.","family":"Jacobson","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery New York University Langone Health  New York New York U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenneth S.","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology NYU Langone Health  New York New York U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alec","family":"Vaezi","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery New York University Langone Health  New York New York U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2011-4211","authenticated-orcid":false,"given":"Moses","family":"Tam","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology NYU Langone Health  New York New York U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8221-5077","authenticated-orcid":false,"given":"Babak","family":"Givi","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery New York University Langone Health  New York New York U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,1,7]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-012-2343-6"},{"key":"e_1_2_7_3_1","unstructured":"American Cancer Society.Cancer facts & figures 2017. 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