{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T05:05:18Z","timestamp":1767675918247,"version":"3.40.5"},"reference-count":38,"publisher":"Wiley","issue":"S9","license":[{"start":{"date-parts":[[2022,1,27]],"date-time":"2022-01-27T00:00:00Z","timestamp":1643241600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:sec><jats:title>Objectives\/Hypothesis<\/jats:title><jats:p>Develop a patient\u2010specific tissue engineered construct for laryngeal reconstruction following a partial laryngectomy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Bench and animal research.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A construct made from a porous polyethylene scaffold shaped in a canine\u2010specific configuration and seeded with autologous canine adipose\u2010derived stem cells in fibrin glue was implanted in a canine following a partial laryngectomy. After 1\u2009year, the construct was first evaluated <jats:italic>in vivo<\/jats:italic> with high\u2010speed imaging and acoustic\u2013aerodynamic measures. It was then explanted and evaluated histologically.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The canine study at 1\u2009year revealed the construct provided voicing (barking) with acoustic and aerodynamic measures within normal ranges. The canine was able to eat and breathe normally without long\u2010term support. The construct was integrated with epithelialization of all areas except the medial portion of the vocal fold structure. No anti\u2010infective agents were needed after the standard perioperative medications were completed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study provided a successful first step toward developing a patient\u2010specific composite construct for patients undergoing partial laryngectomies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>NA <jats:italic>Laryngoscope<\/jats:italic>, 132:S1\u2013S11, 2022<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.30029","type":"journal-article","created":{"date-parts":[[2022,1,27]],"date-time":"2022-01-27T14:25:27Z","timestamp":1643293527000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["A Tissue Engineered Construct for Laryngeal Regeneration: A <scp>Proof\u2010of\u2010Concept<\/scp> Device Design Study"],"prefix":"10.1002","volume":"132","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6541-9687","authenticated-orcid":false,"given":"David G.","family":"Lott","sequence":"first","affiliation":[{"name":"Head and Neck Regenerative Medicine Laboratory Mayo Clinic Arizona  Scottsdale Arizona U.S.A."},{"name":"Division of Laryngology, Department of Otolaryngology\u2013Head and Neck Surgery Mayo Clinic Arizona  Phoenix Arizona U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manisha","family":"Shah","sequence":"additional","affiliation":[{"name":"Head and Neck Regenerative Medicine Laboratory Mayo Clinic Arizona  Scottsdale Arizona U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheryl","family":"Myers","sequence":"additional","affiliation":[{"name":"Head and Neck Regenerative Medicine Laboratory Mayo Clinic Arizona  Scottsdale Arizona U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"McPhail","sequence":"additional","affiliation":[{"name":"Head and Neck Regenerative Medicine Laboratory Mayo Clinic Arizona  Scottsdale Arizona U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juergen","family":"Neubauer","sequence":"additional","affiliation":[{"name":"Head and Neck Regenerative Medicine Laboratory Mayo Clinic Arizona  Scottsdale Arizona U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jason","family":"Struthers","sequence":"additional","affiliation":[{"name":"Department of Pathology and Population Medicine of Midwestern University's College of Veterinary Medicine  Glendale Arizona U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cathy S.","family":"Madsen","sequence":"additional","affiliation":[{"name":"Head and Neck Regenerative Medicine Laboratory Mayo Clinic Arizona  Scottsdale Arizona U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danielle","family":"Grandjean","sequence":"additional","affiliation":[{"name":"Head and Neck Regenerative Medicine Laboratory Mayo Clinic Arizona  Scottsdale Arizona U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephanie R. 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