{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T01:03:47Z","timestamp":1788829427256,"version":"build-2803163510"},"reference-count":32,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2022,2,15]],"date-time":"2022-02-15T00:00:00Z","timestamp":1644883200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2022,2,15]],"date-time":"2022-02-15T00:00:00Z","timestamp":1644883200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Preoperative anterior commissure (AC) evaluation in glottic cancer is crucial for therapeutic decisions. Endoscopy is often inadequate to precisely detect the presence of cancer in the AC; thus, computed tomography (CT) scan could help. We investigated the relation between AC thickness on CT scan (in mm), AC involvement by cancer at histology, and radiologic signs of anterior paraglottic space (PGS) infiltration.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design<\/jats:title>\n                    <jats:p>Retrospective observational study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>An experienced radiologist retrospectively measured AC thickness and identified signs of anterior PGS infiltration on pretreatment contrast\u2010enhanced CT scans of 80 patients with primary glottic cancer. The gold standard to define the presence of cancer in the AC was histology. The receiver operating characteristic (ROC) curves were used to determine the potential cut\u2010off values of AC thickness (Youden index method) able to maximize both sensitivity and specificity in identifying the presence of cancer in the AC at histology and PGS infiltration on CT scan.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      AC was significantly thicker in patients with cancer in the AC at histology (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u2009.001) and in patients with PGS infiltration on CT scan (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u2009.001). The cut\u2010off values to discriminate the presence of cancer at histology and PGS infiltration on CT scan were 3.62 and 2.6\u2009mm, respectively. We found a substantial agreement between anterior PGS infiltration on CT scan and the presence of cancer in the AC at histology (Cohen Kappa:\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.70).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>AC thickness and radiologic signs of PGS infiltration on pretreatment CT scan could represent a method to predict the presence of cancer in the AC at histology.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Level of Evidence<\/jats:title>\n                    <jats:p>\n                      4\n                      <jats:italic>Laryngoscope<\/jats:italic>\n                      , 132:2427\u20132433, 2022\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/lary.30060","type":"journal-article","created":{"date-parts":[[2022,2,15]],"date-time":"2022-02-15T07:41:27Z","timestamp":1644910887000},"page":"2427-2433","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Radiological Findings in Laryngeal Anterior Commissure Invasion:\n                    <scp>CT<\/scp>\n                    Scan Highlights"],"prefix":"10.1002","volume":"132","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2156-8434","authenticated-orcid":false,"given":"Giovanni","family":"Cristalli","sequence":"first","affiliation":[{"name":"Otorhinolaryngology Unit Ospedali Riuniti Padova Sud \u201cMadre Teresa di Calcutta\u201d Hospital  Monselice Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonello","family":"Vidiri","sequence":"additional","affiliation":[{"name":"Radiology and Diagnostic Imaging Department IRCCS Regina Elena National Cancer Institute  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Mercante","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences Humanitas University  Pieve Emanuele Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2066-9572","authenticated-orcid":false,"given":"Fabio","family":"Ferreli","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences Humanitas University  Pieve Emanuele Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0738-8223","authenticated-orcid":false,"given":"Armando","family":"De Virgilio","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences Humanitas University  Pieve Emanuele Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Filippo","family":"Donelli","sequence":"additional","affiliation":[{"name":"Radiology Unit Ospedali Riuniti Padova Sud \u201cMadre Teresa di Calcutta\u201d Hospital  Monselice Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigi","family":"Dav\u00ec","sequence":"additional","affiliation":[{"name":"Radiology Unit Ospedali Riuniti Padova Sud \u201cMadre Teresa di Calcutta\u201d Hospital  Monselice Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierpaola","family":"Gasparin","sequence":"additional","affiliation":[{"name":"Pathological Anatomy Unit Ospedali Riuniti Padova Sud \u201cMadre Teresa di Calcutta\u201d Hospital  Monselice Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrizia","family":"Cocco","sequence":"additional","affiliation":[{"name":"Pathological Anatomy Unit Ospedali Riuniti Padova Sud \u201cMadre Teresa di Calcutta\u201d Hospital  Monselice Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabiola","family":"Giudici","sequence":"additional","affiliation":[{"name":"Unit of Biostatistics, Epidemiology and Public Health, Department of Cardiac, Thoracic, Vascular Sciences and Public Health University of Padua  Padua Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0758-2376","authenticated-orcid":false,"given":"Francesca","family":"Boscolo Nata","sequence":"additional","affiliation":[{"name":"Otorhinolaryngology Unit Ospedali Riuniti Padova Sud \u201cMadre Teresa di Calcutta\u201d Hospital  Monselice Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,2,15]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/ajot.2000.16159"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.24012"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.28395"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-199201000-00014"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-006-0138-3"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-018-5261-4"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-8140(97)00196-5"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1258\/0022215011907235"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215116000487"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anorl.2015.08.017"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-020-05869-0"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nic.2012.08.008"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep30353"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/RCT.0000000000000196"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers12051074"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016489.2011.562538"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mlg.0000161329.75600.9d"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otc.2012.08.006"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.25176"},{"key":"e_1_2_6_21_1","first-page":"49","volume-title":"TNM 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