{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T01:45:42Z","timestamp":1767923142507,"version":"3.49.0"},"reference-count":40,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2022,2,17]],"date-time":"2022-02-17T00:00:00Z","timestamp":1645056000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100006303","name":"Associa\u00e7\u00e3o Fundo de Incentivo \u00e0 Pesquisa","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006303","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:sec><jats:title>Objectives\/Hypothesis<\/jats:title><jats:p>To evaluate the presence of laryngopharyngeal reflux (LPR) and the potential association between presence of LPR symptoms and obstructive sleep apnea (OSA) in a representative sample from a population\u2010based study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Cross\u2010sectional study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Participants of the follow\u2010up of the Epidemiological Sleep Study were evaluated. Sleep was assessed through questionnaires and polysomnography. The presence of LPR was based on the questionnaire Reflux Score Index (RSI), and scores higher than 13 were suggestive of LPR. A general linear model test was used for comparison of continuous data and Pearson's chi\u2010square test was used to compare categorical variables. Predictors of LPR were obtained by regression analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>701 were enrolled (54.8% female, 45.2% male; mean age, 50.2\u00a0\u00b1\u200913.3\u2009years). The mean apnea\u2010hypopnea index score was 17\u2009\u00b1\u200918.3 events\/hr, and the mean RSI score was 7.0\u2009\u00b1\u20098.1. LPR was found in 17% of the volunteers, whereas OSA was present in 38.5% of the sample. Specifically, in those patients with OSA, the prevalence of LPR was 45.4%; however, there was no statistically significant association between LPR and the presence of OSA. The severity of OSA was not associated with RSI score. The presence of LPR was associated with older age, smoking, excessive daytime sleepiness and worse quality of life and sleep scores questionnaires.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Age, smoking, but not body mass index, were associated with LPR. There was not statistically significant association of LPR with OSA. Individuals with symptoms of LPR had greater drowsiness and worse quality of life and sleep.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>3 <jats:italic>Laryngoscope<\/jats:italic>, 132:1877\u20131882, 2022<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.30061","type":"journal-article","created":{"date-parts":[[2022,2,17]],"date-time":"2022-02-17T10:32:09Z","timestamp":1645093929000},"page":"1877-1882","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Assessment of Laryngopharyngeal Reflux and Obstructive Sleep Apnea: A Population\u2010Based Study"],"prefix":"10.1002","volume":"132","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6972-9658","authenticated-orcid":false,"given":"Milena de Almeida Torres","family":"Campanholo","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology and Head and Neck Surgery Universidade Federal de Sao Paulo  Sao Paulo Brazil"},{"name":"Department of Otorhinolaringology Faculdade de Medicina do ABC  Santo Andre Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabio de Azevedo","family":"Caparroz","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology and Head and Neck Surgery Universidade Federal de Sao Paulo  Sao Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatiana de Aguiar","family":"Vidigal","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology and Head and Neck Surgery Universidade Federal de Sao Paulo  Sao Paulo Brazil"},{"name":"Department of Psychobiology Universidade Federal de Sao Paulo  Sao Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caio Henrique","family":"Kenchian","sequence":"additional","affiliation":[{"name":"Department of Medicine Universidade Federal de Sao Paulo  Sao Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monica Levy","family":"Andersen","sequence":"additional","affiliation":[{"name":"Department of Psychobiology Universidade Federal de Sao Paulo  Sao Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sergio","family":"Tufik","sequence":"additional","affiliation":[{"name":"Department of Psychobiology Universidade Federal de Sao Paulo  Sao Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernanda Louise Martinho","family":"Haddad","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology and Head and Neck Surgery Universidade Federal de Sao Paulo  Sao Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,2,17]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.b.20120"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/coa.12914"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2005.41217.x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.2003.01606.x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-012-2028-1"},{"key":"e_1_2_6_7_1","volume-title":"The AASM Manual for the Scoring of Sleep and Associated Events: Rules, Terminology and Technical Specifications, Version 2.0.3","author":"Berry RB","year":"2014"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.2109080"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2009.10.005"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1053\/smrv.2002.0260"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjoto.2018.09.006"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11325-018-1691-x"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.14-0970"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-004-1416-8"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mehy.2009.04.042"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215109004976"},{"key":"e_1_2_6_17_1","unstructured":"IBGE\u2010 Instituto Brasileiro de Geografia e Estat\u00edstica. 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