{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T19:31:52Z","timestamp":1792697512791,"version":"4.5.0"},"reference-count":18,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2022,2,28]],"date-time":"2022-02-28T00:00:00Z","timestamp":1646006400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2022,2,28]],"date-time":"2022-02-28T00:00:00Z","timestamp":1646006400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2022,12]]},"abstract":"\n Objectives<\/jats:title>\n \n The management of incidental findings of FDG\u2010avid tonsils on PET\/CT (IFT) is unclear. We aimed to explore the prevalence of malignancy in IFT, identify risk factors for malignancy, and calculate optimal cutoffs of maximum standardized uptake values (SUV\n max<\/jats:sub>\n ) to discriminate between benign and malignant lesions.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n All patients who were tonsillectomized at our institution because of IFT from October 2011 to December 2020 were included. Patients undergoing PET\/CT due to suspected tonsillar disease or cancer of unknown primary were excluded.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n In total, 77 patients were included, of which 11 (14%) of them had IFT malignancy. Dysphagia (\n p<\/jats:italic>\n \u00a0=\u00a00.019) and alcohol abuse (\n p<\/jats:italic>\n \u00a0=\u00a00.035) were associated with malignancy. Absolute SUV\n max<\/jats:sub>\n cutoff (\u22659: sensitivity 100%; specificity 53%) was superior to SUV\n max<\/jats:sub>\n side\u2010to\u2010side ratio (\u22651.5: sensitivity 64%; specificity 70%) to discriminate between benign and malignant lesions.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n We recommend tonsillectomy for patients with IFT displaying SUV\n max<\/jats:sub>\n \u2009\u2265\u20099.0, ratio\u2009\u2265\u20091.5, or symptoms or findings suggesting malignancy.\n <\/jats:p>\n <\/jats:sec>\n \n Level of Evidence<\/jats:title>\n \n 3\n Laryngoscope<\/jats:italic>\n , 132:2370\u20132378, 2022\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/lary.30081","type":"journal-article","created":{"date-parts":[[2022,2,28]],"date-time":"2022-02-28T09:15:03Z","timestamp":1646039703000},"page":"2370-2378","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Incidental\n FDG<\/scp>\n \u2010Avid Focuses in Palatine Tonsils on\n PET<\/scp>\n \/\n CT<\/scp>"],"prefix":"10.1002","volume":"132","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3494-278X","authenticated-orcid":false,"given":"Kasper Basse","family":"Reinholdt","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck Surgery Aarhus University Hospital Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9 Henrique","family":"Dias","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine and PET Centre Aarhus University Hospital Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camilla Molich","family":"Hoff","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine and PET Centre Aarhus University Hospital Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars Christian","family":"Gormsen","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine and PET Centre Aarhus University Hospital Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tejs Ehlers","family":"Klug","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck Surgery Aarhus University Hospital Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,2,28]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.crad.2016.02.023"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/147323000703500207"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1148\/rg.254045136"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13244-014-0349-x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.crad.2018.10.007"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.10091479"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/coa.12055"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/MNM.0b013e3283299a52"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599817742579"},{"key":"e_1_2_6_11_1","article-title":"Clinical relevance of 18F\u2010FDG\u2010PET\/CT incidental findings","volume":"67","author":"Hadad ZS","year":"2020","journal-title":"Dan Med J"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1148\/rg.254035156"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000011040"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/RLU.0000000000000255"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2014.05.020"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/coa.12981"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2017.09.019"},{"key":"e_1_2_6_18_1","first-page":"558","article-title":"A randomized controlled trial for perioperative morbidity in microdebrider versus cold instrument dissection tonsillectomy","volume":"93","author":"Pruegsanusak K","year":"2010","journal-title":"J Med Assoc 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Laryngoscope"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lary.30081","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/lary.30081","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lary.30081","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T20:29:22Z","timestamp":1773001762000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/lary.30081"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2,28]]},"references-count":18,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2022,12]]}},"alternative-id":["10.1002\/lary.30081"],"URL":"https:\/\/doi.org\/10.1002\/lary.30081","archive":["Portico"],"relation":{},"ISSN":["0023-852X","1531-4995"],"issn-type":[{"value":"0023-852X","type":"print"},{"value":"1531-4995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,2,28]]},"assertion":[{"value":"2021-11-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication 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