{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T12:16:48Z","timestamp":1771503408925,"version":"3.50.1"},"reference-count":43,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,4,23]],"date-time":"2022-04-23T00:00:00Z","timestamp":1650672000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>To characterize clinical factors associated with esthesioneuroblastoma treatment delays and determine the impact of these delays on overall survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Retrospective database analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The 2004\u20132016 National Cancer Database was queried for patients with esthesioneuroblastoma managed by primary surgery and adjuvant radiation. Durations of diagnosis\u2010to\u2010treatment initiation (DTI), diagnosis\u2010to\u2010treatment end (DTE), surgery\u2010to\u2010RT initiation (SRT), radiotherapy treatment (RTD), and total treatment package (TTP) were analyzed. The cohort was split into two groups for each delay interval using the median time as the threshold.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 814 patients (39.6% female, 88.5% white) with mean\u2009\u00b1\u2009SD age of 52.6\u2009\u00b1\u200915.1\u2009years who underwent both esthesioneuroblastoma surgery and adjuvant radiotherapy were queried. Median DTI, DTE, SRT, RTD, and TTP were 34, 140, 55, 45, and 101\u2009days, respectively. A significant association was identified between increased regional radiation dose above 66\u2009Gy and decreased DTI (OR\u00a0=\u00a00.54, 95% CI 0.35\u20130.83, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.01) and increased RTD (OR\u00a0=\u00a03.94, 95% CI 2.36\u20136.58, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) durations. Chemotherapy administration was linked with decreased SRT (OR\u00a0=\u00a00.64, 95% CI 0.47\u20130.89, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.01) and TTP (OR\u00a0=\u00a00.59, 95% CI 0.43\u20130.82, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.001) durations. Cox proportional\u2010hazards analysis revealed that increased RTD was associated with decreased survival (HR\u00a0=\u00a01.80, 95% CI 1.26\u20132.57, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.005), independent of age, sex, race, regional radiation dose, facility volume, facility type, insurance status, modified Kadish stage, chemotherapy status, Charlson\u2010Deyo comorbidity index, and surgical margins.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Delays during, and prolongation of radiotherapy for esthesioneuroblastoma appears to be associated with decreased survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>4 <jats:italic>Laryngoscope<\/jats:italic>, 133:764\u2013772, 2023<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.30136","type":"journal-article","created":{"date-parts":[[2022,4,23]],"date-time":"2022-04-23T11:33:49Z","timestamp":1650713629000},"page":"764-772","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Impact of esthesioneuroblastoma treatment delays on overall patient survival"],"prefix":"10.1002","volume":"133","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6576-0970","authenticated-orcid":false,"given":"Kotaro","family":"Tsutsumi","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery University of California  Irvine California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8269-1949","authenticated-orcid":false,"given":"Khwaja H.","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery University of California  Irvine California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Khodayar","family":"Goshtasbi","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery University of California  Irvine California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sina J.","family":"Torabi","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery University of California  Irvine California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmed","family":"Mohyeldin","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery University of California  Irvine California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank P.K.","family":"Hsu","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery University of California  Irvine California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3475-0718","authenticated-orcid":false,"given":"Edward C.","family":"Kuan","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery University of California  Irvine California USA"},{"name":"Department of Neurological Surgery University of California  Irvine California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,4,23]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.133.3.276"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/00016480310001295"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.22027"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.24770"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.24608"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.25643"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2018.11.021"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599818797605"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.27247"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2016.6905"},{"key":"e_1_2_6_12_1","unstructured":"Head and Neck Cancers. 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