{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T17:45:56Z","timestamp":1788457556810,"version":"build-2803163510"},"reference-count":33,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,5,16]],"date-time":"2022-05-16T00:00:00Z","timestamp":1652659200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100006380","name":"Rehabilitation Research and Development Service","doi-asserted-by":"publisher","award":["RX002813"],"award-info":[{"award-number":["RX002813"]}],"id":[{"id":"10.13039\/100006380","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2023,2]]},"abstract":"\n Objective<\/jats:title>\n To design a deep learning model based on multimodal magnetic resonance image (MRI) sequences for automatic parotid neoplasm classification, and to improve the diagnostic decision\u2010making in clinical settings.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n First, multimodal MRI sequences were collected from 266 patients with parotid neoplasms, and an artificial intelligence (AI)\u2010based deep learning model was designed from scratch, combining the image classification network of Resnet and the Transformer network of Natural language processing. Second, the effectiveness of the deep learning model was improved through the multi\u2010modality fusion of MRI sequences, and the fusion strategy of various MRI sequences was optimized. In addition, we compared the effectiveness of the model in the parotid neoplasm classification with experienced radiologists.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n The deep learning model delivered reliable outcomes in differentiating benign and malignant parotid neoplasms. The model, which was trained by the fusion of T2\u2010weighted, postcontrast T1\u2010weighted, and diffusion\u2010weighted imaging (\n b<\/jats:italic>\n \u00a0=\u00a01000\u2009s\/mm\n 2<\/jats:sup>\n ), produced the best result, with an accuracy score of 0.85, an area under the receiver operator characteristic (ROC) curve of 0.96, a sensitivity score of 0.90, and a specificity score of 0.84. In addition, the multi\u2010modal paradigm exhibited reliable outcomes in diagnosing the pleomorphic adenoma and the Warthin tumor, but not in the identification of the basal cell adenoma.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n An accurate and efficient AI based classification model was produced to classify parotid neoplasms, resulting from the fusion of multimodal MRI sequences. The effectiveness certainly outperformed the model with single MRI images or single MRI sequences as input, and potentially, experienced radiologists.<\/jats:p>\n <\/jats:sec>\n \n Level of Evidence<\/jats:title>\n \n 3\n Laryngoscope<\/jats:italic>\n , 133:327\u2013335, 2023\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/lary.30154","type":"journal-article","created":{"date-parts":[[2022,5,16]],"date-time":"2022-05-16T09:28:54Z","timestamp":1652693334000},"page":"327-335","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["A Deep Learning Model for Classification of Parotid Neoplasms Based on Multimodal Magnetic Resonance Image Sequences"],"prefix":"10.1002","volume":"133","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5177-9948","authenticated-orcid":false,"given":"Xu","family":"Liu","sequence":"first","affiliation":[{"name":"ENT Institute and Department of Otorhinolaryngology, Eye & ENT Hospital Fudan University Shanghai China"},{"name":"ENT Institute and Department of Otorhinolaryngology, Eye & ENT Hospital NHC Key Laboratory of Hearing Medicine (Fudan University) Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yucheng","family":"Pan","sequence":"additional","affiliation":[{"name":"Department of Radiology, Eye & ENT Hospital Fudan University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Zhang","sequence":"additional","affiliation":[{"name":"ENT Institute and Department of Otorhinolaryngology, Eye & ENT Hospital Fudan University Shanghai China"},{"name":"ENT Institute and Department of Otorhinolaryngology, Eye & ENT Hospital NHC Key Laboratory of Hearing Medicine (Fudan University) Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongfang","family":"Sha","sequence":"additional","affiliation":[{"name":"ENT Institute and Department of Otorhinolaryngology, Eye & ENT Hospital Fudan University Shanghai China"},{"name":"ENT Institute and Department of Otorhinolaryngology, Eye & ENT Hospital NHC Key Laboratory of Hearing Medicine (Fudan University) Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shihui","family":"Wang","sequence":"additional","affiliation":[{"name":"Lab of Sensing and Computing Shanghai Advanced Research Institute, Chinese Academy of Sciences Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0207-5367","authenticated-orcid":false,"given":"Hongzhe","family":"Li","sequence":"additional","affiliation":[{"name":"Research Service, VA Loma Linda Healthcare System Loma Linda California U.S.A."},{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Loma Linda University School of Medicine Loma Linda California 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