{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,9]],"date-time":"2026-08-09T16:56:14Z","timestamp":1786294574449,"version":"build-2736575974"},"reference-count":31,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,6,12]],"date-time":"2022-06-12T00:00:00Z","timestamp":1654992000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>The Chronic Obstructive Sialadenitis Symptoms questionnaire (COSS) was created to assess chronic sialadenitis symptoms and treatment response, but its development lacked patient input and validation. We analyzed COSS responses and feedback from sialadenitis patients and physician experts to create the novel obstructive Salivary Problem Impact Test (SPIT), a new standardized measure of sialadenitis\u2010associated symptoms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We analyzed COSS responses via exploratory factor analysis (EFA) to identify essential symptom domains and reduce overlap in questions. Sialadenitis patients evaluated the significance of index symptoms identified from the literature review. Expert physicians rated symptom relevance in clinical assessment. An updated questionnaire (SPIT) was piloted with both patient and expert interviews to optimize structure and readability. The SPIT was assessed for internal consistency, construct validity, and test\u2013retest stability.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>EFA of 310 COSS responses demonstrated 3 main symptom domains (functional impact, pain, swelling) that explained 58.4% of response variance. Results were not statistically different when collapsing from 11 to 5 question response options. Experts (<jats:italic>n<\/jats:italic>\u00a0=\u00a05) ranked gland swelling, mealtime pain, and foul taste as most clinically important, while patients (<jats:italic>n<\/jats:italic>\u00a0=\u00a012) ranked swelling, non\u2010mealtime pain, and difficulty eating as most bothersome. Most patients experienced sialadenitis\u2010related functional or psychosocial impairment. Following interviews for question refinement, a 25\u2010question survey was finalized. SPIT responses from 50 sialadenitis patients demonstrated internal consistency (Cronbach's alpha\u00a0=\u00a00.96), 14\u2010day stability (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), and agreement with Oral Health Impact Profile\u201014 scores (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>We developed the SPIT instrument to improve usability and content validity in chronic sialadenitis evaluation. The psychometric assessment demonstrated high construct validity and test\u2013retest reliability. Further work will assess longitudinal changes with treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>4 <jats:italic>Laryngoscope<\/jats:italic>, 133:539\u2013546, 2023<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.30244","type":"journal-article","created":{"date-parts":[[2022,6,13]],"date-time":"2022-06-13T06:56:03Z","timestamp":1655103363000},"page":"539-546","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["An Updated <scp>Patient\u2010Centered<\/scp>\u00a0Sialadenitis Instrument: The Obstructive Salivary Problem Impact Test (SPIT)"],"prefix":"10.1002","volume":"133","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8060-2954","authenticated-orcid":false,"given":"Arushi","family":"Gulati","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery University of California, San Francisco  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David M.","family":"Cognetti","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Thomas Jefferson University Hospitals  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David S.","family":"Cohen","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Southern California Permanente Medical Group  Harbor City California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Allison","family":"Ogden","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Washington University in St. Louis  St. Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barry M.","family":"Schaitkin","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology University of Pittsburgh Medical Center  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rohan R.","family":"Walvekar","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head &amp; Neck Surgery Louisiana State University Health Sciences Center  New Orleans Louisiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William R.","family":"Ryan","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery University of California, San Francisco  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0778-1044","authenticated-orcid":false,"given":"Jolie L.","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery University of California, San Francisco  San Francisco California USA"},{"name":"Department of Veterans Affairs Medical Center Surgery Service  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,6,12]]},"reference":[{"issue":"11","key":"e_1_2_7_2_1","first-page":"882","article-title":"Salivary gland disorders","volume":"89","author":"Wilson KF","year":"2014","journal-title":"Am Fam Physician"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjoms.2014.09.017"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/01945998211017444"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-013-2418-z"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.25759"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599820957256"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.25521"},{"key":"e_1_2_7_9_1","article-title":"Novel multidisciplinary salivary gland society (MSGS) questionnaire: an international consensus","volume":"132","author":"Buchholzer S","year":"2021","journal-title":"The Laryngoscope"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02291575"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.21315\/eimj2019.11.2.6"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0528.1997.tb00941.x"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1368-8375(00)00063-4"},{"key":"e_1_2_7_14_1","volume-title":"Derivation of New Readability Formulas","author":"Kincaid J","year":"1975"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbi.2008.08.010"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbi.2019.103208"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2009.04.021"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2010.05.004"},{"issue":"1","key":"e_1_2_7_19_1","first-page":"12","article-title":"The xerostomia inventory: a multi\u2010item approach to measuring dry mouth","volume":"16","author":"Thomson WM","year":"1999","journal-title":"Community Dent Health"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(01)01512-7"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2010.143743"},{"issue":"6","key":"e_1_2_7_22_1","first-page":"1259","article-title":"UKSj\u00f6gren's interest group. 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