{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T16:44:19Z","timestamp":1777913059196,"version":"3.51.4"},"reference-count":31,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,7,2]],"date-time":"2022-07-02T00:00:00Z","timestamp":1656720000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>Anaplastic thyroid carcinoma (ATC) is a rare but highly aggressive form of thyroid cancer. Increasingly, patients with ATC present with concurrent foci of well\u2010differentiated thyroid carcinoma (WDTC); however, the significance of these pathologic findings remains unclear. The objective of this study is to determine whether the presence of WDTC within anaplastic tumors is a prognosticator of survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective cohort study of all cases of biopsy\u2010proven ATC managed at a tertiary care academic medical center from 2002 to 2020 was performed. Mean age at diagnosis, median survival time, and locations of distant metastases were assessed. The impact of clinical markers such as presence of differentiation, demographic variables, and oncologic information on overall survival was also determined via univariate and multivariate analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Forty\u2010five patients were included in this study. The mean age at diagnosis was 69.1\u2009years. Median survival time was 6.1\u2009months after diagnosis. The most common location of distant metastases was the lung (40%). The presence of limited areas of WDTC in patients with predominantly anaplastic thyroid tumors was not significantly associated with improved outcomes (<jats:italic>p<\/jats:italic>\u00a0=\u20090.509). Smaller tumor size and use of chemotherapy in ATC patients were significantly associated with prolonged survival (<jats:italic>p<\/jats:italic>\u00a0=\u20090.026 and 0.010, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Clinical outcomes for ATC remain poor. The presence of foci of differentiation within anaplastic thyroid tumors does not appear to improve overall survival\u2014the anaplastic component evidently drives outcomes. Further studies into novel therapies are needed to improve survival in ATC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>4 <jats:italic>Laryngoscope<\/jats:italic>, 133:437\u2013442, 2023<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.30277","type":"journal-article","created":{"date-parts":[[2022,7,2]],"date-time":"2022-07-02T15:53:25Z","timestamp":1656777205000},"page":"437-442","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Anaplastic Transformation of Differentiated Thyroid Carcinoma"],"prefix":"10.1002","volume":"133","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4351-1962","authenticated-orcid":false,"given":"Alice C.","family":"Yu","sequence":"first","affiliation":[{"name":"Department of Head and Neck Surgery David Geffen School of Medicine at University of California Los Angeles, Los Angeles (UCLA)  Los Angeles California U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4427-6634","authenticated-orcid":false,"given":"Albert Y.","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery David Geffen School of Medicine at University of California Los Angeles, Los Angeles (UCLA)  Los Angeles California U.S.A."},{"name":"University of California Los Angeles, Los Angeles (UCLA) Head and Neck Cancer Program  Los Angeles California U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David Alex","family":"Cronkite","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery David Geffen School of Medicine at University of California Los Angeles, Los Angeles (UCLA)  Los Angeles California U.S.A."},{"name":"University of California Los Angeles, Los Angeles (UCLA) Head and Neck Cancer Program  Los Angeles California U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dipti","family":"Sajed","sequence":"additional","affiliation":[{"name":"University of California Los Angeles, Los Angeles (UCLA) Head and Neck Cancer Program  Los Angeles California U.S.A."},{"name":"Department of Pathology David Geffen School of Medicine at University of California Los Angeles, Los Angeles (UCLA)  Los Angeles California U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7068-9534","authenticated-orcid":false,"given":"Maie A.","family":"St. John","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery David Geffen School of Medicine at University of California Los Angeles, Los Angeles (UCLA)  Los Angeles California U.S.A."},{"name":"University of California Los Angeles, Los Angeles (UCLA) Head and Neck Cancer Program  Los Angeles California 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