{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T16:35:14Z","timestamp":1784997314488,"version":"3.55.0"},"reference-count":75,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,6,29]],"date-time":"2022-06-29T00:00:00Z","timestamp":1656460800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2019M3A9H2032424"],"award-info":[{"award-number":["2019M3A9H2032424"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2019M3E5D5064110"],"award-info":[{"award-number":["2019M3E5D5064110"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2020R1I1A1A01051844"],"award-info":[{"award-number":["2020R1I1A1A01051844"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>To assess the predictive value of various risk factors for pharyngocutaneous fistula (PCF) after total laryngectomy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The characteristics of each study were collected from six databases up to January of 2022. Risk for bias was assessed using the QUADAS\u20102 tool.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 58 studies in 9845 patients were included in the analysis. The incidence of PCF was 21.69%, 95% confidence intervals (CI) [0.20; 0.24] in the included studies. Age (OR\u00a0=\u00a01.33, 95% CI [1.12; 1.58]), postoperative anemia (OR\u00a0=\u00a02.29, 95% CI [1.47; 3.57]), diabetes mellitus (OR\u00a0=\u00a01.81, 95% CI [1.20; 2.71]), tumor site (above or below the glottis) (OR\u00a0=\u00a01.47, 95% CI [1.15; 1.88]), previous radiation therapy (OR\u00a0=\u00a02.06, 95% CI [1.56; 2.72]), previous tracheostomy (OR\u00a0=\u00a01.26, 95% CI [1.04; 1.53]), surgery timing (salvage vs. primary) (OR\u00a0=\u00a02.08, 95% CI [1.46; 2.97]), extended total laryngectomy (including pharyngectomy) (OR\u00a0=\u00a01.96, 95% CI [1.28; 3.00]), primary tracheoesophageal puncture (OR\u00a0=\u00a00.61, 95% CI [0.40; 0.93]), and postoperative hypoproteinemia (OR\u00a0=\u00a09.98, 95% CI [3.68; 27.03]) were significantly associated with the occurrence of PCF. In view of predictive ability, postoperative hypoproteinemia showed the highest accuracy (sensitivity\u00a0=\u00a051%, specificity\u00a0=\u00a090%, area under the curve\u00a0=\u00a00.84).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Multiple patient\u2010, disease\u2010, and surgery\u2010related factors are risk factors for PCF. In particular, postoperative hypoproteinemia could be a good predictive factor for PCF in patients undergoing total laryngectomy. <jats:italic>Laryngoscope<\/jats:italic>, 133:742\u2013754, 2023<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.30278","type":"journal-article","created":{"date-parts":[[2022,6,30]],"date-time":"2022-06-30T06:14:20Z","timestamp":1656569660000},"page":"742-754","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Predictive Value of Risk Factors for Pharyngocutaneous Fistula After Total Laryngectomy"],"prefix":"10.1002","volume":"133","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9248-5572","authenticated-orcid":false,"given":"Do Hyun","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery, Seoul Saint Mary's Hospital, College of Medicine The Catholic University of Korea  Seoul South 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