{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T04:24:41Z","timestamp":1788668681632,"version":"build-2803163510"},"reference-count":32,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,7,8]],"date-time":"2022-07-08T00:00:00Z","timestamp":1657238400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["P30 CA008748"],"award-info":[{"award-number":["P30 CA008748"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Limited data is available to guide non\u2010surgical management of Stage T4 larynx and hypopharynx cancer patients who have inoperable disease or refuse surgery. We aim to review the nonoperative management of T4 laryngeal and hypopharyngeal cancer and report the long\u2010term therapeutic and functional outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We reviewed the nonoperative management of T4 laryngeal (<jats:italic>n<\/jats:italic>\u00a0=\u200944) and hypopharyngeal (<jats:italic>n<\/jats:italic>\u00a0=\u200953) cancer from 1997 to 2015 and performed a univariate analysis (UVA).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The 2\u2010\/5\u2010year OS rates were 73%\/38% for larynx patients and 52%\/29% for hypopharynx patients. Locoregional failure (LRF) occurred in 25% and 19% of larynx and hypopharynx patients, respectively. On UVA of the larynx subset, N3 nodal status and non\u2010intensity\u2010modulated radiation therapy were negatively associated with OS; treatment with radiation therapy alone impacted disease\u2010free survival; and age &gt;70 was associated with LRF. On UVA of the hypopharynx subset, only T4b status significantly impacted OS. In the larynx and hypopharynx groups, 68% and 85% received a percutaneous endoscopic gastrostomy (PEG) tube and 32% and 40% received a tracheostomy tube, respectively. At the last follow\u2010up visit, 66% of our larynx cohort had neither tracheostomy or PEG placed and 40% of our hypopharynx cohort had neither.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We report better than previously noted outcomes among T4 larynx and hypopharynx patients who have unresectable disease or refuse surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>4 <jats:italic>Laryngoscope<\/jats:italic>, 133:1138\u20131145, 2023<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.30279","type":"journal-article","created":{"date-parts":[[2022,7,8]],"date-time":"2022-07-08T09:49:51Z","timestamp":1657273791000},"page":"1138-1145","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Outcomes for Organ Preservation with Chemoradiation Therapy for <scp>T4<\/scp> Larynx and Hypopharynx Cancer"],"prefix":"10.1002","volume":"133","author":[{"given":"Amgad","family":"Eita","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology Memorial Sloan Kettering  New York New York U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9877-5717","authenticated-orcid":false,"given":"Nader","family":"Mohamed","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Memorial Sloan Kettering  New York New York U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alisa","family":"Rybkin","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Memorial Sloan Kettering  New York New York U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung Julie","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Memorial Sloan Kettering  New York New York 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U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emad","family":"Sadaka","sequence":"additional","affiliation":[{"name":"Department of Clinical Oncology Kafrelsheikh University  Kafrelsheikh Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Sherman","sequence":"additional","affiliation":[{"name":"Department of Medicine Memorial Sloan Kettering  New York New York U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lara","family":"Dunn","sequence":"additional","affiliation":[{"name":"Department of Medicine Memorial Sloan Kettering  New York New York U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Cracchiolo","sequence":"additional","affiliation":[{"name":"Department of Surgery Memorial Sloan Kettering  New York New York U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard 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