{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T11:22:28Z","timestamp":1792840948198,"version":"4.5.0"},"reference-count":29,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,7,23]],"date-time":"2022-07-23T00:00:00Z","timestamp":1658534400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To objectively identify and quantitate presenting nasal symptoms in patients with a septal perforation using the validated NOSE\u2010Perf scale.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Case series retrospective review.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The medical records from August 2018 through January 2022 of patients at a tertiary care academic center with a septal perforation, and who completed the NOSE\u2010Perf questionnaire, were reviewed. Perforation symptoms were identified and quantified using the 12\u2010item NOSE\u2010Perf scale (score range 0\u201348). NOSE\u2010Perf findings were correlated to patient demographics, perforation etiology, and perforation length. NOSE\u2010Perf scores of patients who pursued treatment were compared with those who did not.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>NOSE\u2010Perf data were collected from 202 patients. Nasal crusting was noted in 94.1% of patients and was the most severe symptom reported (mean 2.9 of 4.0). Nasal congestion, difficulty breathing, and nasal obstruction followed in prevalence and severity. The mean total NOSE\u2010Perf score was 23.7. Linear regression analysis demonstrated a weakly negative association of NOSE\u2010Perf score with patient age and weakly positive association with increasing perforation length. NOSE\u2010Perf scores were significantly higher in women and in patients pursuing treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This is the first study to use the validated NOSE\u2010Perf scale to objectively characterize and establish baseline septal perforation symptomatology. The NOSE\u2010Perf scale can play a role in the standardization of perforation evaluation and treatment outcomes assessment. <jats:italic>Laryngoscope<\/jats:italic>, 133:1315\u20131320, 2023<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.30299","type":"journal-article","created":{"date-parts":[[2022,7,23]],"date-time":"2022-07-23T10:13:35Z","timestamp":1658571215000},"page":"1315-1320","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Presenting Symptomatology for Patients With Nasal Septal Perforation: Application of the <scp>NOSE\u2010Perf<\/scp> Scale"],"prefix":"10.1002","volume":"133","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4088-5195","authenticated-orcid":false,"given":"Cullen M.","family":"Taylor","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Mayo Clinic in Arizona  Phoenix Arizona U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8672-0310","authenticated-orcid":false,"given":"Michael J.","family":"Marino","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Mayo Clinic in Arizona  Phoenix Arizona U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen F.","family":"Bansberg","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Mayo Clinic in Arizona  Phoenix Arizona U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,7,23]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOO.0000000000000224"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.22965"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0038-1654675"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.29109"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.29901"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215121003248"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamafacial.2019.0020"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamafacial.2016.1367"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoto.2013.5996"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1089\/fpsam.2020.0155"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-008-0690-0"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.2500\/ajra.2016.30.4324"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/coa.13622"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anl.2010.05.006"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1258\/002221502761698720"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mlg.0000256455.01473.72"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjorl.2020.12.018"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/coa.13031"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.28415"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599821992010"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2003.09.016"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599812472881"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1177\/194589240401800603"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1080\/00016489.2019.1688388"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.25144"},{"key":"e_1_2_6_27_1","first-page":"128","article-title":"Intranasal steroids and septum perforation\u2014an overlooked complication? 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